A snapshot of CNVs in the pig genome

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  • PLoS One

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DOI

  • Molekylær Genetik og Systembiologi
  • Department of Genetics and Biotechnology
Recent studies of mammalian genomes have uncovered the extent of copy number variation (CNV) that contributes to phenotypic diversity, including health and disease status. Here we report a first account of CNVs in the pig genome covering part of the chromosomes 4, 7, 14, and 17 already sequenced and assembled. A custom tiling oligonucleotide array was used with a median probe spacing of 409 bp for screening 12 unrelated Duroc boars that are founders of a large family material. After a strict CNV calling pipeline, 37 copy number variable regions (CNVRs) across all four chromosomes were identified, with five CNVRs overlapping segmental duplications, three overlapping pig unigenes and one overlapping a RefSeq pig mRNA. This CNV snapshot analysis is the first of its kind in the porcine genome and constitutes the basis for a better understanding of porcine phenotypes and genotypes with the prospect of identifying important economic traits.
Original languageEnglish
JournalP L o S One
Volume3
Issue12
Pages (from-to)e3916
ISSN1932-6203
DOIs
Publication statusPublished - 2008

    Research areas

  • Animals, Comparative Genomic Hybridization, Gene Dosage, Genome, Oligonucleotide Array Sequence Analysis, Reproducibility of Results, Reverse Transcriptase Polymerase Chain Reaction, Sus scrofa

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