A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein

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  • Laure Yatime
  • ,
  • Nicolas S. Merle, INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France, France
  • Annette G. Hansen
  • Niels Anton Friis, INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France
  • ,
  • Jakob A. Østergaard
  • Mette Bjerre
  • Lubka T. Roumenina, INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France
  • ,
  • Steffen Thiel
  • Peter Kristensen, Department of Chemistry and Bioscience, Aalborg University
  • ,
  • Gregers R. Andersen
Original languageEnglish
Article number2822
JournalFrontiers in Immunology
Volume9
Number of pages11
ISSN1664-3224
DOIs
Publication statusPublished - 29 Nov 2018

    Research areas

  • Bacteriolysis, Complement, Hemolysis, Paroxysmal nocturnal hemoglobinuria, Pathogen mimicry, Single-domain antibody, Terminal pathway inhibition

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