A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein

Laure Yatime*, Nicolas S. Merle, Annette G. Hansen, Niels Anton Friis, Jakob A. Østergaard, Mette Bjerre, Lubka T. Roumenina, Steffen Thiel, Peter Kristensen, Gregers R. Andersen

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

8 Citations (Scopus)
229 Downloads (Pure)
Original languageEnglish
Article number2822
JournalFrontiers in Immunology
Volume9
Number of pages11
ISSN1664-3224
DOIs
Publication statusPublished - 29 Nov 2018

Keywords

  • Bacteriolysis
  • Complement
  • Hemolysis
  • Paroxysmal nocturnal hemoglobinuria
  • Pathogen mimicry
  • Single-domain antibody
  • Terminal pathway inhibition

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