A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jesper Bertram Bramsen
  • Malgorzata M Pakula
  • ,
  • Thomas B Hansen
  • Claus Bus
  • Niels Langkjær, Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Denmark
  • Dalibor Odadzic, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
  • Romualdas Smicius, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
  • Suzy L Wengel, RiboTask ApS, Denmark
  • Jyoti Chattopadhyaya, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
  • Joachim W Engels, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
  • Piet Herdewijn, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Netherlands
  • Jesper Wengel, Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Denmark
  • Jørgen Kjems
Original languageEnglish
JournalNucleic Acids Research
Volume38
Issue17
Pages (from-to)5761-5773
Number of pages13
ISSN0305-1048
DOIs
Publication statusPublished - 2010

    Research areas

  • Cell Line, Tumor, Genes, Reporter, Humans, Nucleic Acids, RNA Interference, RNA, Antisense, RNA, Small Interfering

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