A randomized controlled trial of acute health effects from exposure to indoor ultrafine particles

Karin Rosenkilde Laursen; Berit Brøndum Rasmussen; Bernadette Rosati; Vibeke Heitmann Gutzke; Kirsten Østergaard; Peter Ravn; Søren Kjærgaard; Marianne Glasius; Torben Sigsgaard

A randomized controlled trial of acute health effects from exposure to indoor ultrafine particles

Karin Rosenkilde Laursen^*, Berit Brøndum Rasmussen, Bernadette Rosati, Vibeke Heitmann Gutzke, Kirsten Østergaard, Peter Ravn, Søren Kjærgaard, Marianne Glasius, Torben Sigsgaard

^*Corresponding author for this work

Research output: Contribution to conference › Paper › Research › peer-review

Abstract

We examined acute health effects of short-term exposure to emissions from typical indoor sources. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions each lasting five hours (cooking, burning candles and clean air). During exposures, particle characteristics, volatile organic compounds, and self-reported symptoms were measured. Health effects were examined at baseline, then 5 and 24 hours after exposure start. Overall, no changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and burning candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. Thus, emissions from cooking and candles might exert mild inflammation and discomfort among asthmatics, why precautionary measures should be taken to lower indoor particle levels.

Original language	English
Publication date	2022
Publication status	Published - 2022
Event	17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022 - Kuopio, Finland Duration: 12 Jun 2022 → 16 Jun 2022

Conference

Conference	17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022
Country/Territory	Finland
City	Kuopio
Period	12/06/2022 → 16/06/2022

Keywords

Human exposure study
Indoor particle sources
Respiratory inflammatory response
Self-reported symptoms
Young mild asthmatics

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@conference{79b6099929584e99839977eb5af436ff,

title = "A randomized controlled trial of acute health effects from exposure to indoor ultrafine particles",

abstract = "We examined acute health effects of short-term exposure to emissions from typical indoor sources. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions each lasting five hours (cooking, burning candles and clean air). During exposures, particle characteristics, volatile organic compounds, and self-reported symptoms were measured. Health effects were examined at baseline, then 5 and 24 hours after exposure start. Overall, no changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and burning candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. Thus, emissions from cooking and candles might exert mild inflammation and discomfort among asthmatics, why precautionary measures should be taken to lower indoor particle levels.",

keywords = "Human exposure study, Indoor particle sources, Respiratory inflammatory response, Self-reported symptoms, Young mild asthmatics",

author = "Laursen, {Karin Rosenkilde} and Rasmussen, {Berit Br{\o}ndum} and Bernadette Rosati and Gutzke, {Vibeke Heitmann} and Kirsten {\O}stergaard and Peter Ravn and S{\o}ren Kj{\ae}rgaard and Marianne Glasius and Torben Sigsgaard",

note = "Publisher Copyright: {\textcopyright} 2022 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022. All rights reserved.; 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022 ; Conference date: 12-06-2022 Through 16-06-2022",

year = "2022",

language = "English",

}

A randomized controlled trial of acute health effects from exposure to indoor ultrafine particles. / Laursen, Karin Rosenkilde; Rasmussen, Berit Brøndum; Rosati, Bernadette et al.
2022. Paper presented at 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022, Kuopio, Finland.

Research output: Contribution to conference › Paper › Research › peer-review

TY - CONF

T1 - A randomized controlled trial of acute health effects from exposure to indoor ultrafine particles

AU - Laursen, Karin Rosenkilde

AU - Rasmussen, Berit Brøndum

AU - Rosati, Bernadette

AU - Gutzke, Vibeke Heitmann

AU - Østergaard, Kirsten

AU - Ravn, Peter

AU - Kjærgaard, Søren

AU - Glasius, Marianne

AU - Sigsgaard, Torben

PY - 2022

Y1 - 2022

N2 - We examined acute health effects of short-term exposure to emissions from typical indoor sources. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions each lasting five hours (cooking, burning candles and clean air). During exposures, particle characteristics, volatile organic compounds, and self-reported symptoms were measured. Health effects were examined at baseline, then 5 and 24 hours after exposure start. Overall, no changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and burning candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. Thus, emissions from cooking and candles might exert mild inflammation and discomfort among asthmatics, why precautionary measures should be taken to lower indoor particle levels.

AB - We examined acute health effects of short-term exposure to emissions from typical indoor sources. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions each lasting five hours (cooking, burning candles and clean air). During exposures, particle characteristics, volatile organic compounds, and self-reported symptoms were measured. Health effects were examined at baseline, then 5 and 24 hours after exposure start. Overall, no changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and burning candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. Thus, emissions from cooking and candles might exert mild inflammation and discomfort among asthmatics, why precautionary measures should be taken to lower indoor particle levels.

KW - Human exposure study

KW - Indoor particle sources

KW - Respiratory inflammatory response

KW - Self-reported symptoms

KW - Young mild asthmatics

UR - http://www.scopus.com/inward/record.url?scp=85159176429&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:85159176429

T2 - 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022

Y2 - 12 June 2022 through 16 June 2022

ER -

A randomized controlled trial of acute health effects from exposure to indoor ultrafine particles

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Keywords

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