A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

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  • Naomi E Allen, United Kingdom
  • Andrew W Roddam, United Kingdom
  • Sabina Sieri, Italy
  • Heiner Boeing, Germany
  • Marianne Uhre Jakobsen, Denmark
  • Kim Overvad
  • Anne Tjønneland, Denmark
  • Jytte Halkjaer, Denmark
  • Paolo Vineis, Italy
  • Paolo Contiero, Italy
  • Domenico Palli, Italy
  • Rosario Tumino, Italy
  • Amalia Mattiello, Italy
  • Rudolf Kaaks, Germany
  • Sabine Rohrmann, Germany
  • Antonia Trichopoulou, Greece
  • Demosthenes Zilis, Greece
  • Yvoni Koumantaki, Greece
  • Petra H Peeters, Netherlands
  • H Bas Bueno-de-Mesquita, Netherlands
  • Aurelio Barricarte, Spain
  • Laudina Rodríguez, Spain
  • Miren Dorronsoro, Spain
  • Maria-José Sánchez, Spain
  • María Dolores Chirlaque, Spain
  • Laura Esquius, Spain
  • Jonas Manjer, Sweden
  • Peter Wallström, Sweden
  • Börje Ljungberg, Sweden
  • Göran Hallmans, Sweden
  • Sheila Bingham, United Kingdom
  • Kay-Tee Khaw, United Kingdom
  • Paolo Boffetta, France
  • Teresa Norat, United Kingdom
  • Traci Mouw, United Kingdom
  • Elio Riboli, United Kingdom
  • Institute of Epidemiology and Social Medicine
  • Department of Clinical Epidemiology
Previous case-control studies have suggested that a high intake of animal foods and its associated nutrients are associated with an increased risk of renal cell carcinoma, although data from prospective studies are limited. We report here on the relationship between macronutrient intake and renal cell carcinoma incidence among 435,293 participants enrolled in the European Prospective Investigation into Cancer and Nutrition. Cox proportional hazard models were used to examine the association of dietary intake of fat, protein, carbohydrate, fiber and cholesterol and risk of renal cell carcinoma adjusted for age, sex, center, height, body mass index, physical activity, education, smoking, menopausal status, alcohol and energy intake. During an average 8.8 years of follow-up, 507 renal cell carcinoma cases occurred. Risk of renal cell carcinoma was not associated with macronutrient intake, including nutrients derived from animal sources. Our results indicate that macronutrient intake is not associated with risk of renal cell carcinoma in this cohort of European men and women.
Original languageEnglish
JournalInternational Journal of Cancer
Volume125
Issue4
Pages (from-to)982-7
Number of pages5
ISSN0020-7136
DOIs
Publication statusPublished - 2009

    Research areas

  • Adult, Aged, Body Mass Index, Carcinoma, Renal Cell, Cohort Studies, Confounding Factors (Epidemiology), Dietary Fats, Female, Follow-Up Studies, Food Habits, Humans, Kidney Neoplasms, Male, Meat, Middle Aged, Prospective Studies, Questionnaires, Risk Assessment, Risk Factors

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