A positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis

TY - JOUR

T1 - A positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis

AU - Abrahams, S.

AU - Leigh, P. N.

AU - Kew, J. J.M.

AU - Goldstein, L. H.

AU - Lloyd, C. M.L.

AU - Brooks, D. J.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Positron emission tomography (PET) was used to investigate the location of cerebral cortical and subcortical abnormalities in non-demented patients with amyotrophic lateral sclerosis (ALS). Involvement of the frontal lobes was investigated with a task of executive frontal lobe function (verbal fluency/word generation), using a PET activation paradigm. Two groups of ALS patients defined by the presence or absence of cognitive impairment were tested. ALS patients who had cognitive impairments showed a region of cortical and subcortical dysfunction which extended across a wide area of the frontal lobes, and included the insular cortex and thalamic nuclear complex. These findings support the notion that extra-motor involvement is relatively common in ALS and broadens concepts of selective vulnerability in ALS. © 1995 Elsevier Science B.V. All rights reserved.

AB - Positron emission tomography (PET) was used to investigate the location of cerebral cortical and subcortical abnormalities in non-demented patients with amyotrophic lateral sclerosis (ALS). Involvement of the frontal lobes was investigated with a task of executive frontal lobe function (verbal fluency/word generation), using a PET activation paradigm. Two groups of ALS patients defined by the presence or absence of cognitive impairment were tested. ALS patients who had cognitive impairments showed a region of cortical and subcortical dysfunction which extended across a wide area of the frontal lobes, and included the insular cortex and thalamic nuclear complex. These findings support the notion that extra-motor involvement is relatively common in ALS and broadens concepts of selective vulnerability in ALS. © 1995 Elsevier Science B.V. All rights reserved.

KW - Amyotrophic lateral sclerosis

KW - Frontal lobes

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0029000507&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(95)00060-F

DO - 10.1016/0022-510X(95)00060-F

M3 - Journal article

C2 - 7595618

AN - SCOPUS:0029000507

SN - 0022-510X

VL - 129

SP - 44

EP - 46

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - SUPPL.

ER -