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A positive-negative mode of population covariation links brain connectivity, demographics and behavior

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  • Stephen M. Smith, University of Oxford
  • ,
  • Thomas E. Nichols, The University of Warwick
  • ,
  • Diego Vidaurre
  • Anderson M. Winkler, University of Oxford
  • ,
  • Timothy E.J. Behrens, University of Oxford
  • ,
  • Matthew F. Glasser, Washington University St. Louis
  • ,
  • Kamil Ugurbil, University of Minnesota
  • ,
  • Deanna M. Barch, Washington University St. Louis
  • ,
  • David C. Van Essen, Washington University St. Louis
  • ,
  • Karla L. Miller, University of Oxford

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

Original languageEnglish
JournalNature Neuroscience
Pages (from-to)1565-1567
Number of pages3
Publication statusPublished - 1 Nov 2015
Externally publishedYes

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