A Population-based Study on the Prevalence and Associated Factors of Age-related Macular Degeneration in Northern Iran the Gilan Eye Study

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  • Hassan Behboudi, Guilan University of Medical Sciences
  • ,
  • Homayoun Nikkhah, Shahid Behesthi University of Medical Sciences, Shahid Beheshti University of Medical Sciences
  • ,
  • Yousef Alizadeh, Guilan University of Medical Sciences
  • ,
  • Marzieh Katibeh
  • Mojgan Pakbin, Noor Eye Hospital, Tehran University of Medical Sciences
  • ,
  • Hamid Ahmadieh, Shahid Behesthi University of Medical Sciences
  • ,
  • Hamideh Sabbaghi, Shahid Behesthi University of Medical Sciences, Shahid Beheshti University of Medical Sciences
  • ,
  • Ramin Nourinia, Shahid Beheshti University of Medical Sciences
  • ,
  • Saeed Karimi, Shahid Behesthi University of Medical Sciences, Shahid Beheshti University of Medical Sciences
  • ,
  • Nazanin Behnaz, Shahid Behesthi University of Medical Sciences
  • ,
  • Golbarg Piryaiee, Shahid Behesthi University of Medical Sciences
  • ,
  • Mehdi Yaseri, Tehran University of Medical Sciences
  • ,
  • Bahareh Kheiri, Shahid Behesthi University of Medical Sciences
  • ,
  • Siamak Moradian, Shahid Behesthi University of Medical Sciences

Purpose: To estimate the prevalence and associated factors of AMD in an Iranian population in 2014. Methods: In this population-based cross-sectional study, a total of 2975 Iranian residents (age: ≥50 years) from the urban and rural areas of Gilan province were included. The prevalence of different grades of AMD was determined using the International Age-Related Maculopathy Epidemiological Study Group grading system. Results: Of 2975 eligible individuals, 2587 (87.0%) subjects participated and 2275 (76.5%) subjects (62.6 ± 8.8 years old) had gradable fundus photographs. Age- and sex-standardized prevalence of early and late AMD based on the 2016 Iran census were 13.2% (95% confidence interval [CI], 10.6–16.2) and 0.7% (95% CI, 0.4–1.3), respectively. In multivariate analysis, each decade increase in age was associated with the adjusted odds of any (adjusted odds ratio [AOR] = 1.31, 95% CI, 1.09–1.56; P =.0031), early (AOR = 1.27, 95% CI, 1.06–1.53; P =.012) and late AMD (AOR = 2.39, 95% CI, 1.08–5.28; P =.031). Hyperopia was identified to be less frequent in late AMD (AOR = 0.20, 95% CI, 0.04–0.80; P =.024). No significant association was found between AMD and sex, smoking, outdoor working, diabetes, hypertension, pseudophakia, hyperlipidemia and myopia. Conclusion: Gilan Eye Study demonstrated the first estimate of age-specific AMD prevalence in Iran being compatible with other WHO regions. With the expected increase in the life expectancy and aging of Iranians, the number of people affected by AMD will be increasing in future. Healthcare policy makers should be advised to provide more efficient eye care services and preventive strategies in this regard.

Original languageEnglish
JournalOphthalmic Epidemiology
Volume27
Issue3
Pages (from-to)209-218
Number of pages10
ISSN0928-6586
DOIs
Publication statusPublished - 2020

    Research areas

  • Age-related Macular Degeneration, associated factor, Iran, prevalence

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