A placebo-controlled, double-blind, crossover trial on analgesic effect of nitrous oxide-oxygen inhalation

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  • Anni Birgitte Grønbæk, Denmark
  • Peter Svensson
  • Michael Vaeth
  • Ingelise Hansen, Syddansk Universitetsbibliotek. Odense. Intern Procesafdeling, Denmark
  • Sven Poulsen, Denmark
BACKGROUND: The sedative effect of nitrous oxide-oxygen (N2 O/O2 ) inhalation is relatively well established. Less in known about its analgesic effect. AIM: To determine the analgesic effect of N2 O/O2 inhalation on pulp sensitivity and jaw muscle pressure pain threshold in children. DESIGN: A placebo-controlled, double-blind, crossover trial with random allocation to two sequences: atmospheric air at the first session and N2 O/O2 at the second; or N2 O/O2 at the first session and atmospheric air at the second. Measurements included reaction time, pulp pain sensitivity, jaw muscle pressure pain thresholds and a VAS score of overall discomfort from the pain tests. RESULTS: Fifty-six children (12-15 years) completed the study. N2 O/O2 inhalation increased reaction time (P 
Original languageEnglish
JournalInternational Journal of Paediatric Dentistry (Print)
Pages (from-to)69-75
Number of pages7
Publication statusPublished - 2014

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