A Photoswitchable Inhibitor of the Human Serotonin Transporter

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The human serotonin transporter (hSERT) terminates serotonergic signaling through reuptake of neurotransmitter into presynaptic neurons and is a target for many antidepressant drugs. We describe here the development of a photoswitchable hSERT inhibitor, termed azo-escitalopram, that can be reversibly switched between trans and cis configurations using light of different wavelengths. The dark-adapted trans isomer was found to be significantly less active than the cis isomer, formed upon irradiation.

Original languageEnglish
JournalACS Chemical Neuroscience
Volume11
Issue9
Pages (from-to)1231-1237
Number of pages7
ISSN1948-7193
DOIs
Publication statusPublished - May 2020

    Research areas

  • neurotransmitter, photochromic ligand, Photopharmacology, serotonin, transporter

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