A Photoswitchable Inhibitor of the Human Serotonin Transporter

Bichu Cheng, Johannes Morstein, Lucy Kate Ladefoged, Jannick Bang Maesen, Birgit Schiøtt, Steffen Sinning, Dirk Trauner

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The human serotonin transporter (hSERT) terminates serotonergic signaling through reuptake of neurotransmitter into presynaptic neurons and is a target for many antidepressant drugs. We describe here the development of a photoswitchable hSERT inhibitor, termed azo-escitalopram, that can be reversibly switched between trans and cis configurations using light of different wavelengths. The dark-adapted trans isomer was found to be significantly less active than the cis isomer, formed upon irradiation.

Original languageEnglish
JournalACS Chemical Neuroscience
Pages (from-to)1231-1237
Number of pages7
Publication statusPublished - May 2020


  • neurotransmitter
  • photochromic ligand
  • Photopharmacology
  • serotonin
  • transporter

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