A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

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  • Nikos Papadimitriou, Biostatistics Group, International Agency for Research on Cancer, Lyon, France., France
  • David Muller, Department of Epidemiology and Biostatistics, , The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG London, United Kingdom., United Kingdom
  • Piet A van den Brandt, Department of Epidemiology, GROW School for Oncology and Developmental Biology, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands., Netherlands
  • Milan Geybels, Department of Epidemiology, GROW School for Oncology and Developmental Biology, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands., Netherlands
  • Chirag J Patel, Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., United States
  • Marc J Gunter, Biostatistics Group, International Agency for Research on Cancer, Lyon, France., France
  • David S Lopez, Division of Urology, UTHealth McGovern Medical School, Houston, TX, USA., United States
  • Timothy J Key, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., United Kingdom
  • Aurora Perez-Cornago, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., United Kingdom
  • Pietro Ferrari, Biostatistics Group, International Agency for Research on Cancer, Lyon, France., France
  • Paolo Vineis, Italian Institute for Genomic Medicine (IIGM), Turin, Italy;Department of Medical Sciences, University of Turin, Turin, Italy., Italy
  • Elisabete Weiderpass, Biostatistics Group, International Agency for Research on Cancer, Lyon, France., France
  • Heiner Boeing, Department of Epidemiology, German Institute for Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany., Germany
  • Antonio Agudo, Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain., Spain
  • María-José Sánchez, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Spain
  • Kim Overvad
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. r.kaaks@dkfz-heidelberg.de., Germany
  • Renee T Fortner, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. r.kaaks@dkfz-heidelberg.de., Germany
  • Domenico Palli, Cancer Risk Factors and Life-Style Epidemiology Unit. Institute for Cancer Research, Prevention and Clinical Network - ISPRO, 50141, Florence, Italy., Italy
  • Isabel Drake, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sweden
  • Anders Bjartell, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sweden
  • Carmen Santiuste, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Spain
  • Bas H Bueno-de-Mesquita, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia., Malaysia
  • Vittorio Krogh, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Italy
  • Anne Tjønneland, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Denmark
  • Dorthe Furstrand Lauritzen, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Denmark
  • Aurelio Barricarte Gurrea, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Spain
  • José Ramón Quirós, Public Health Directorate, Asturias, Spain., Spain
  • Pär Stattin, Department of Surgical Sciences, Thoracic Surgery, Uppsala University, Uppsala, Sweden., Sweden
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Greece., Greece
  • Georgia Martimianaki, Hellenic Health Foundation, Athens, Greece., Greece
  • Anna Karakatsani, 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University Hospital, Haidari, Greece., Greece
  • Elin Thysell, Department of Medical Biosciences, Pathology, Department of Biobank Research, Umeå University, Umeå, Sweden., Sweden
  • Ingegerd Johansson, Departments of Odontology, Section of Cardiology, Biobank Research, Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Sweden
  • Fulvio Ricceri, Department of Clinical and Biological Sciences, University of Turin, Orbassano, TO, Italy; Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO), University of Turin, Orbassano, TO, Italy., Italy
  • Rosario Tumino, Cancer Registry and Histopathology Unit, "Civic-M.P.Arezzo" Hospital, ASP, Via Dante N° 109, 97100 Ragusa, Italy., Italy
  • Nerea Larrañaga, Epidemiology and Health Information, Public Health Division of Gipuzkoa, Basque Regional Health Department, San Sebastian, Spain., Spain
  • Kay Tee Khaw, University of Cambridge School of Clinical Medicine, Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom., United Kingdom
  • Elio Riboli, Department of Epidemiology and Biostatistics, , The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG London, United Kingdom., United Kingdom
  • Ioanna Tzoulaki, Department of Epidemiology and Biostatistics, , The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG London, United Kingdom., United Kingdom
  • Konstantinos K Tsilidis, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, London, W2 1PG, UK. k.tsilidis@imperial.ac.uk., United Kingdom

PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive.

METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS).

RESULTS: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS.

CONCLUSIONS: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

Original languageEnglish
JournalEuropean Journal of Nutrition
Volume59
Issue7
Pages (from-to)2929-2937
Number of pages9
ISSN1436-6207
DOIs
Publication statusPublished - Oct 2020

    Research areas

  • diet, nutrition, epidemiology, cohort study, prostate cancer, Diet, Nutrition, Cohort study, Epidemiology, Prostate cancer, CARBOHYDRATE, OVARIAN-CANCER, DIET, SCALE PROSPECTIVE COHORT, PRODUCTS, CALCIUM, PHYSICAL-ACTIVITY, INDEX, QUESTIONNAIRE

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