A novel nano-composite material for optically stimulated luminescence dosimetry

Camilla Lønborg Nielsen; Rosana Martinez Turtos; Martin Bondesgaard; Jacob Søgaard Nyemann; Mads Lykke Jensen; Bo Brummerstedt Iversen; Ludvig Muren; Brian Julsgaard; Peter Balling

doi:10.1021/acs.nanolett.1c04384

A novel nano-composite material for optically stimulated luminescence dosimetry

Camilla Lønborg Nielsen^*, Rosana Martinez Turtos, Martin Bondesgaard, Jacob Søgaard Nyemann, Mads Lykke Jensen, Bo Brummerstedt Iversen, Ludvig Muren, Brian Julsgaard, Peter Balling

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

Radiotherapy is a well-established and important treatment for cancer tumors, and advanced technologies can deliver doses in complex three-dimensional geometries tailored to each patient’s specific anatomy. A 3D dosimeter, based on optically stimulated luminescence (OSL), could provide a high accuracy and reusable tool for verifying such dose delivery. Nanoparticles of an OSL material embedded in a transparent matrix have previously been proposed as an inexpensive dosimeter, which can be read out using laser-based methods. Here, we show that Cu-doped LiF nanocubes (nano-LiF:Cu) are excellent candidates for 3D OSL dosimetry owing to their high sensitivity, dose linearity, and stability at ambient conditions. We demonstrate a scalable synthesis technique producing a material with the attractive properties of a single dosimetric trap and a single near-ultraviolet emission line well separated from visible-light stimulation sources. The observed transparency and light yield of silicone sheets with embedded nanocubes hold promise for future 3D OSL-based dosimetry.

Original language	English
Journal	Nano Letters
Volume	22
Issue	4
Pages (from-to)	1566-1572
Number of pages	7
ISSN	1530-6984
DOIs	https://doi.org/10.1021/acs.nanolett.1c04384
Publication status	Published - Feb 2022

Keywords

3D Dosimetry
Flow Synthesis
Nanoparticles
Optically Stimulated Luminescence

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@article{a851a3402d91438ab75393370df28119,

title = "A novel nano-composite material for optically stimulated luminescence dosimetry",

abstract = "Radiotherapy is a well-established and important treatment for cancer tumors, and advanced technologies can deliver doses in complex three-dimensional geometries tailored to each patient{\textquoteright}s specific anatomy. A 3D dosimeter, based on optically stimulated luminescence (OSL), could provide a high accuracy and reusable tool for verifying such dose delivery. Nanoparticles of an OSL material embedded in a transparent matrix have previously been proposed as an inexpensive dosimeter, which can be read out using laser-based methods. Here, we show that Cu-doped LiF nanocubes (nano-LiF:Cu) are excellent candidates for 3D OSL dosimetry owing to their high sensitivity, dose linearity, and stability at ambient conditions. We demonstrate a scalable synthesis technique producing a material with the attractive properties of a single dosimetric trap and a single near-ultraviolet emission line well separated from visible-light stimulation sources. The observed transparency and light yield of silicone sheets with embedded nanocubes hold promise for future 3D OSL-based dosimetry.",

keywords = "3D Dosimetry, Flow Synthesis, Nanoparticles, Optically Stimulated Luminescence",

author = "Nielsen, {Camilla L{\o}nborg} and {Martinez Turtos}, Rosana and Martin Bondesgaard and Nyemann, {Jacob S{\o}gaard} and Jensen, {Mads Lykke} and Iversen, {Bo Brummerstedt} and Ludvig Muren and Brian Julsgaard and Peter Balling",

year = "2022",

month = feb,

doi = "10.1021/acs.nanolett.1c04384",

language = "English",

volume = "22",

pages = "1566--1572",

journal = "Nano Letters",

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TY - JOUR

T1 - A novel nano-composite material for optically stimulated luminescence dosimetry

AU - Nielsen, Camilla Lønborg

AU - Martinez Turtos, Rosana

AU - Bondesgaard, Martin

AU - Nyemann, Jacob Søgaard

AU - Jensen, Mads Lykke

AU - Iversen, Bo Brummerstedt

AU - Muren, Ludvig

AU - Julsgaard, Brian

AU - Balling, Peter

PY - 2022/2

Y1 - 2022/2

N2 - Radiotherapy is a well-established and important treatment for cancer tumors, and advanced technologies can deliver doses in complex three-dimensional geometries tailored to each patient’s specific anatomy. A 3D dosimeter, based on optically stimulated luminescence (OSL), could provide a high accuracy and reusable tool for verifying such dose delivery. Nanoparticles of an OSL material embedded in a transparent matrix have previously been proposed as an inexpensive dosimeter, which can be read out using laser-based methods. Here, we show that Cu-doped LiF nanocubes (nano-LiF:Cu) are excellent candidates for 3D OSL dosimetry owing to their high sensitivity, dose linearity, and stability at ambient conditions. We demonstrate a scalable synthesis technique producing a material with the attractive properties of a single dosimetric trap and a single near-ultraviolet emission line well separated from visible-light stimulation sources. The observed transparency and light yield of silicone sheets with embedded nanocubes hold promise for future 3D OSL-based dosimetry.

AB - Radiotherapy is a well-established and important treatment for cancer tumors, and advanced technologies can deliver doses in complex three-dimensional geometries tailored to each patient’s specific anatomy. A 3D dosimeter, based on optically stimulated luminescence (OSL), could provide a high accuracy and reusable tool for verifying such dose delivery. Nanoparticles of an OSL material embedded in a transparent matrix have previously been proposed as an inexpensive dosimeter, which can be read out using laser-based methods. Here, we show that Cu-doped LiF nanocubes (nano-LiF:Cu) are excellent candidates for 3D OSL dosimetry owing to their high sensitivity, dose linearity, and stability at ambient conditions. We demonstrate a scalable synthesis technique producing a material with the attractive properties of a single dosimetric trap and a single near-ultraviolet emission line well separated from visible-light stimulation sources. The observed transparency and light yield of silicone sheets with embedded nanocubes hold promise for future 3D OSL-based dosimetry.

KW - 3D Dosimetry

KW - Flow Synthesis

KW - Nanoparticles

KW - Optically Stimulated Luminescence

U2 - 10.1021/acs.nanolett.1c04384

DO - 10.1021/acs.nanolett.1c04384

M3 - Journal article

C2 - 35130696

SN - 1530-6984

VL - 22

SP - 1566

EP - 1572

JO - Nano Letters

JF - Nano Letters

IS - 4

ER -

A novel nano-composite material for optically stimulated luminescence dosimetry

Abstract

Keywords

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