A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Astros Th Skuladottir, deCODE Genetics
  • ,
  • Gyda Bjornsdottir, deCODE Genetics
  • ,
  • Gudmar Thorleifsson, deCODE Genetics
  • ,
  • G. Bragi Walters, deCODE Genetics, University of Iceland
  • ,
  • Muhammad Sulaman Nawaz, deCODE Genetics, University of Iceland
  • ,
  • Kristjan Helgi Swerford Moore, deCODE Genetics
  • ,
  • Pall I. Olason, deCODE Genetics
  • ,
  • Thorgeir E. Thorgeirsson, deCODE Genetics
  • ,
  • Brynja Sigurpalsdottir, deCODE Genetics, Reykjavík University
  • ,
  • Gardar Sveinbjornsson, deCODE Genetics
  • ,
  • Hannes P. Eggertsson, deCODE Genetics
  • ,
  • Sigurdur H. Magnusson, deCODE Genetics
  • ,
  • Asmundur Oddsson, deCODE Genetics
  • ,
  • Anna Bjornsdottir, Laeknasetrid Clinic
  • ,
  • Arnor Vikingsson, Landspitali University Hospital
  • ,
  • Olafur A. Sveinsson, Landspitali University Hospital
  • ,
  • Maria G. Hrafnsdottir, Landspitali University Hospital
  • ,
  • Gudrun R. Sigurdardottir, Laeknasetrid Clinic
  • ,
  • Bjarni V. Halldorsson, deCODE Genetics
  • ,
  • Thomas Folkmann Hansen, University of Copenhagen
  • ,
  • Helene Paarup, University of Southern Denmark
  • ,
  • Christian Erikstrup
  • Kaspar Nielsen, Aalborg University
  • ,
  • Mads Klokker, University of Copenhagen
  • ,
  • Mie Topholm Bruun, University of Southern Denmark
  • ,
  • Erik Sorensen, University of Copenhagen
  • ,
  • Karina Banasik, University of Copenhagen
  • ,
  • Kristoffer S. Burgdorf, University of Copenhagen
  • ,
  • Ole Birger Pedersen, Neastved Hospital
  • ,
  • Henrik Ullum, University of Copenhagen
  • ,
  • Ingileif Jonsdottir, deCODE Genetics, University of Iceland
  • ,
  • Hreinn Stefansson, deCODE Genetics
  • ,
  • Kari Stefansson, deCODE Genetics, University of Iceland

Bell’s palsy is the most common cause of unilateral facial paralysis and is defined as an idiopathic and acute inability to control movements of the facial muscles on the affected side. While the pathogenesis remains unknown, previous studies have implicated post-viral inflammation and resulting compression of the facial nerve. Reported heritability estimates of 4–14% suggest a genetic component in the etiology and an autosomal dominant inheritance has been proposed. Here, we report findings from a meta-analysis of genome-wide association studies uncovering the first unequivocal association with Bell’s palsy (rs9357446-A; P = 6.79 × 10−23, OR = 1.23; Ncases = 4714, Ncontrols = 1,011,520). The variant also confers risk of intervertebral disc disorders (P = 2.99 × 10−11, OR = 1.04) suggesting a common pathogenesis in part or a true pleiotropy.

Original languageEnglish
Article number4188
JournalScientific Reports
Volume11
Issue1
Number of pages8
ISSN2045-2322
DOIs
Publication statusPublished - Dec 2021

See relations at Aarhus University Citationformats

ID: 213445104