A mega-analysis of genome-wide association studies for major depressive disorder

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Stephan Ripke
  • ,
  • Naomi R Wray
  • ,
  • Cathryn M Lewis
  • ,
  • Steven P Hamilton
  • ,
  • Myrna M Weissman
  • ,
  • Gerome Breen
  • ,
  • Enda M Byrne
  • ,
  • Douglas H R Blackwood
  • ,
  • Dorret I Boomsma
  • ,
  • Sven Cichon
  • ,
  • Andrew C Heath
  • ,
  • Florian Holsboer
  • ,
  • Susanne Lucae
  • ,
  • Pamela A F Madden
  • ,
  • Nicholas G Martin
  • ,
  • Peter McGuffin
  • ,
  • Pierandrea Muglia
  • ,
  • Markus M Noethen
  • ,
  • Brenda P Penninx
  • ,
  • Michele L Pergadia
  • ,
  • James B Potash
  • ,
  • Marcella Rietschel
  • ,
  • Danyu Lin
  • ,
  • Bertram Müller-Myhsok
  • ,
  • Jianxin Shi
  • ,
  • Stacy Steinberg
  • ,
  • Hans J Grabe
  • ,
  • Paul Lichtenstein
  • ,
  • Patrik Magnusson
  • ,
  • Roy H Perlis
  • ,
  • Martin Preisig
  • ,
  • Jordan W Smoller
  • ,
  • Kari Stefansson
  • ,
  • Rudolf Uher
  • ,
  • Zoltan Kutalik
  • ,
  • Katherine E Tansey
  • ,
  • Alexander Teumer
  • ,
  • Alexander Viktorin
  • ,
  • Michael R Barnes
  • ,
  • Thomas Bettecken
  • ,
  • Elisabeth B Binder
  • ,
  • René Breuer
  • ,
  • Victor M Castro
  • ,
  • Susanne E Churchill
  • ,
  • William H Coryell
  • ,
  • Nick Craddock
  • ,
  • Ian W Craig
  • ,
  • Darina Czamara
  • ,
  • Eco J De Geus
  • ,
  • Manuel Mattheisen
  • Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of recent European ancestry (9240 MDD cases and 9519 controls). In the MDD replication phase, we evaluated 554 SNPs in independent samples (6783 MDD cases and 50 695 controls). We also conducted a cross-disorder meta-analysis using 819 autosomal SNPs with P
Original languageEnglish
JournalMolecular Psychiatry
Volume18
Issue4
Pages (from-to)497-511
Number of pages15
ISSN1359-4184
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

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