A longitudinal study of serum cobalamins and its binding proteins in lactating women.

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  • A L Mørkbak, Denmark
  • C H Ramlau-Hansen, Denmark
  • U K Møller, Denmark
  • T B Henriksen, Denmark
  • Jan Møller, Denmark
  • E Nexø
  • Interdisciplinary Nanoscience Center
  • Department of Chemistry
  • Clinical Biochemistry
  • Department of clinical biochemistry
  • The Department of Endocrinology and Metabolism C
  • Department of Molecular Biology
OBJECTIVE: To examine longitudinal changes in serum cobalamins, transcobalamin (TC) and haptocorrin (HC) during lactation and to investigate the influence of vitamin B12 supplementation on these parameters. DESIGN: A 9-month follow-up study. SUBJECTS AND METHODS: Lactating mothers (N=89) including 23 supplemented with vitamin B12 (1-18 microg/daily), 41 partly supplemented and 25 not supplemented. Blood samples collected 3 weeks (baseline) and 4 and 9 months post-partum were analysed for cobalamins, TC and HC. Both the total concentration and the cobalamin-saturated form (holo) of TC and HC were analysed. RESULTS: No significant differences were observed in serum cobalamins or its binding proteins related to supplementation with vitamin B12 or the duration of lactation. Serum cobalamins remained unchanged from 3 weeks to 9 months post-partum. Total TC (holoTC) (median+/-s.e. pmol/l) decreased between 3 weeks (710+/-23 (85+/-12)) and 9 months (602+/-21 (76+/-11)) (P<0.0001 (P=0.0002)), whereas total HC (holoHC) increased from (422+/-11 (300+/-9)) at 4 months to (455+/-13 (317+/-10)) to 9 months post-partum (P<0.0001 (P<0.0001)). CONCLUSION: We report a decrease in TC and an increase in HC during a 9-month period post-partum. No differences were observed between the vitamin B12-supplemented and the unsupplemented groups. Thus, supplementation with vitamin B12 has no impact on the circulating level of serum cobalamins or its binding proteins in a Danish population of lactating mothers.
Udgivelsesdato: 2007-Feb
Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume61
Issue2
Pages (from-to)184-9
Number of pages5
ISSN0954-3007
DOIs
Publication statusPublished - 2006

    Research areas

  • Adult, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Lactation, Longitudinal Studies, Protein Binding, Transcobalamins, Vitamin B 12, Vitamin B Complex

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