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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
- Jesper B Bramsen
- Maria Bach Laursen
- Anne F Nielsen
- Thomas B Hansen
- Claus Bus
- Niels Langkjær, Nucleic Acid Center, University of Southern Denmark, Denmark
- Bolle Ravindra Babu, Nucleic Acid Center, University of Southern Denmark, Denmark
- Torben Højland, Nucleic Acid Center, University of Southern Denmark, Denmark
- Mikhail Abramov, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
- Arthur Van Aerschot, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
- Dalibor Odadzic, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
- Romualdas Smicius, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
- Jens Haas, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
- Cordula Andree, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
- Jharna Barman, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
- Malgorzata Wenska, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
- Puneet Srivastava, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
- Chuanzheng Zhou, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
- Dmytro Honcharenko, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
- Simone Hess, Department of Molecular Biology, Max Planck Institute for Infection Biology, Germany
- Elke Müller, Department of Molecular Biology, Max Planck Institute for Infection Biology, Germany
- Georgii V Bobkov, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russian Federation
- Sergey N Mikhailov, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russian Federation
- Eugenio Fava, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
- Thomas F Meyer, Department of Molecular Biology, Max Planck Institute for Infection Biology, BerlinDepartment of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
- Jyoti Chattopadhyaya, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
- Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
- Joachim W Engels, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
- Piet Herdewijn, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
- Jesper Wengel, Nucleic Acid Center, University of Southern Denmark, Denmark
- Jørgen Kjems
| Original language | English |
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| Journal | Nucleic Acids Research |
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| Volume | 37 |
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| Issue | 9 |
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| Pages (from-to) | 2867-81 |
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| Number of pages | 15 |
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| ISSN | 0305-1048 |
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| DOIs | |
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| Publication status | Published - 2009 |
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- Cell Line, Tumor, Cell Survival, Humans, RNA Interference, RNA Stability, RNA, Small Interfering, RNA-Induced Silencing Complex
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ID: 44941532