A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jesper B Bramsen
  • Maria Bach Laursen
  • Anne F Nielsen
  • Thomas B Hansen
  • Claus Bus
  • Niels Langkjær, Nucleic Acid Center, University of Southern Denmark, Denmark
  • Bolle Ravindra Babu, Nucleic Acid Center, University of Southern Denmark, Denmark
  • Torben Højland, Nucleic Acid Center, University of Southern Denmark, Denmark
  • Mikhail Abramov, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
  • Arthur Van Aerschot, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
  • Dalibor Odadzic, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
  • Romualdas Smicius, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
  • Jens Haas, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
  • Cordula Andree, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
  • Jharna Barman, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
  • Malgorzata Wenska, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
  • Puneet Srivastava, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
  • Chuanzheng Zhou, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
  • Dmytro Honcharenko, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
  • Simone Hess, Department of Molecular Biology, Max Planck Institute for Infection Biology, Germany
  • Elke Müller, Department of Molecular Biology, Max Planck Institute for Infection Biology, Germany
  • Georgii V Bobkov, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russian Federation
  • Sergey N Mikhailov, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russian Federation
  • Eugenio Fava, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
  • Thomas F Meyer, Department of Molecular Biology, Max Planck Institute for Infection Biology, BerlinDepartment of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
  • Jyoti Chattopadhyaya, Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden
  • Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
  • Joachim W Engels, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Germany
  • Piet Herdewijn, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
  • Jesper Wengel, Nucleic Acid Center, University of Southern Denmark, Denmark
  • Jørgen Kjems
Original languageEnglish
JournalNucleic Acids Research
Volume37
Issue9
Pages (from-to)2867-81
Number of pages15
ISSN0305-1048
DOIs
Publication statusPublished - 2009

    Research areas

  • Cell Line, Tumor, Cell Survival, Humans, RNA Interference, RNA Stability, RNA, Small Interfering, RNA-Induced Silencing Complex

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