A hierarchically ordered compacted coil scaffold for tissue regeneration

Yingchun Su; Zhongyang Zhang; Yilin Wan; Yifan Zhang; Zegao Wang; Lasse Hyldgaard Klausen; Peng Huang; MD Dong; Xiaojun Han; Bianxiao Cui; Menglin Chen

doi:10.1038/s41427-020-0234-7

A hierarchically ordered compacted coil scaffold for tissue regeneration

Yingchun Su, Zhongyang Zhang, Yilin Wan, Yifan Zhang, Zegao Wang, Lasse Hyldgaard Klausen, Peng Huang, MD Dong^*, Xiaojun Han^*, Bianxiao Cui, Menglin Chen^*

^*Corresponding author for this work

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

21 Citations (Scopus)

Abstract

Hierarchically ordered scaffold has a great impact on cell patterning and tissue engineering. The introduction of controllable coils into a scaffold offers an additional unique structural feature compared to conventional linear patterned scaffolds and can greatly increase interior complexity and versatility. In this work, 3D coil compacted scaffolds with hierarchically ordered patterns and tunable coil densities created using speed-programmed melt electrospinning writing (sMEW) successfully led to in vitro cell growth in patterns with tunable cell density. Subcutaneous implantation in mice showed great in vivo biocompatibility, as evidenced by no significant increase in tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) levels in mouse serum. In addition, a lumbar vertebra was successfully printed for mesenchymal stem cells to grow in the desired pattern. A long-range patterned matrix composed of programmable short-range compacted coils enabled the design of complex structures, e.g., for tailored implants, by readily depositing short-range coil-compacted secondary architectures along with customized primary design.

Original language	English
Article number	55
Journal	NPG Asia Materials
Volume	12
Issue	1
Number of pages	10
ISSN	1884-4049
DOIs	https://doi.org/10.1038/s41427-020-0234-7
Publication status	Published - 2020

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title = "A hierarchically ordered compacted coil scaffold for tissue regeneration",

abstract = "Hierarchically ordered scaffold has a great impact on cell patterning and tissue engineering. The introduction of controllable coils into a scaffold offers an additional unique structural feature compared to conventional linear patterned scaffolds and can greatly increase interior complexity and versatility. In this work, 3D coil compacted scaffolds with hierarchically ordered patterns and tunable coil densities created using speed-programmed melt electrospinning writing (sMEW) successfully led to in vitro cell growth in patterns with tunable cell density. Subcutaneous implantation in mice showed great in vivo biocompatibility, as evidenced by no significant increase in tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) levels in mouse serum. In addition, a lumbar vertebra was successfully printed for mesenchymal stem cells to grow in the desired pattern. A long-range patterned matrix composed of programmable short-range compacted coils enabled the design of complex structures, e.g., for tailored implants, by readily depositing short-range coil-compacted secondary architectures along with customized primary design.",

author = "Yingchun Su and Zhongyang Zhang and Yilin Wan and Yifan Zhang and Zegao Wang and Klausen, {Lasse Hyldgaard} and Peng Huang and MD Dong and Xiaojun Han and Bianxiao Cui and Menglin Chen",

year = "2020",

doi = "10.1038/s41427-020-0234-7",

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AU - Su, Yingchun

AU - Zhang, Zhongyang

AU - Wan, Yilin

AU - Zhang, Yifan

AU - Wang, Zegao

AU - Klausen, Lasse Hyldgaard

AU - Huang, Peng

AU - Dong, MD

AU - Han, Xiaojun

AU - Cui, Bianxiao

AU - Chen, Menglin

PY - 2020

Y1 - 2020

N2 - Hierarchically ordered scaffold has a great impact on cell patterning and tissue engineering. The introduction of controllable coils into a scaffold offers an additional unique structural feature compared to conventional linear patterned scaffolds and can greatly increase interior complexity and versatility. In this work, 3D coil compacted scaffolds with hierarchically ordered patterns and tunable coil densities created using speed-programmed melt electrospinning writing (sMEW) successfully led to in vitro cell growth in patterns with tunable cell density. Subcutaneous implantation in mice showed great in vivo biocompatibility, as evidenced by no significant increase in tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) levels in mouse serum. In addition, a lumbar vertebra was successfully printed for mesenchymal stem cells to grow in the desired pattern. A long-range patterned matrix composed of programmable short-range compacted coils enabled the design of complex structures, e.g., for tailored implants, by readily depositing short-range coil-compacted secondary architectures along with customized primary design.

AB - Hierarchically ordered scaffold has a great impact on cell patterning and tissue engineering. The introduction of controllable coils into a scaffold offers an additional unique structural feature compared to conventional linear patterned scaffolds and can greatly increase interior complexity and versatility. In this work, 3D coil compacted scaffolds with hierarchically ordered patterns and tunable coil densities created using speed-programmed melt electrospinning writing (sMEW) successfully led to in vitro cell growth in patterns with tunable cell density. Subcutaneous implantation in mice showed great in vivo biocompatibility, as evidenced by no significant increase in tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) levels in mouse serum. In addition, a lumbar vertebra was successfully printed for mesenchymal stem cells to grow in the desired pattern. A long-range patterned matrix composed of programmable short-range compacted coils enabled the design of complex structures, e.g., for tailored implants, by readily depositing short-range coil-compacted secondary architectures along with customized primary design.

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A hierarchically ordered compacted coil scaffold for tissue regeneration

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