A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes. / Rasmussen, Kurt; Sabroe, S; Wohlert, M; Ingerslev, Hans Jakob; Kappel, B; Nielsen, J.

In: International Archives of Occupational and Environmental Health, Vol. 60, No. 6, 1988, p. 419-23.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Rasmussen, K, Sabroe, S, Wohlert, M, Ingerslev, HJ, Kappel, B & Nielsen, J 1988, 'A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes', International Archives of Occupational and Environmental Health, vol. 60, no. 6, pp. 419-23.

APA

Rasmussen, K., Sabroe, S., Wohlert, M., Ingerslev, H. J., Kappel, B., & Nielsen, J. (1988). A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes. International Archives of Occupational and Environmental Health, 60(6), 419-23.

CBE

Rasmussen K, Sabroe S, Wohlert M, Ingerslev HJ, Kappel B, Nielsen J. 1988. A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes. International Archives of Occupational and Environmental Health. 60(6):419-23.

MLA

Rasmussen, Kurt et al. "A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes". International Archives of Occupational and Environmental Health. 1988, 60(6). 419-23.

Vancouver

Rasmussen K, Sabroe S, Wohlert M, Ingerslev HJ, Kappel B, Nielsen J. A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes. International Archives of Occupational and Environmental Health. 1988;60(6):419-23.

Author

Rasmussen, Kurt ; Sabroe, S ; Wohlert, M ; Ingerslev, Hans Jakob ; Kappel, B ; Nielsen, J. / A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes. In: International Archives of Occupational and Environmental Health. 1988 ; Vol. 60, No. 6. pp. 419-23.

Bibtex

@article{e210cf64927a409ca1206d302d563608,
title = "A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes",
abstract = "Metal workers exposed to trichloroethylene for the degreasing of metals were studied to evaluate the genotoxicity of this exposure. For 15 workers presently exposed to high doses of trichloroethylene there was no difference from unexposed persons with respect to sperm count and morphology, and a small increase of two fluorescent bodies (YFF%) in spermatozoa. In contrast, there was a highly significant increase in frequency of structural aberrations (breaks, gaps, translocation, deletions, inversions) and hyperdiploid cells in cultured lymphocytes from trichloroethylene degreasers. As control groups, physicians from chemically non-exposed surroundings and a concurrently sampled reference from cytogenetic investigations were used. This study indicates positive correlations between exposure to trichloroethylene and somatic chromosome aberrations, whereas no effect on male germ cells could be demonstrated.",
keywords = "Adult, Chromosome Aberrations, Environmental Exposure, Humans, Lymphocytes, Male, Metallurgy, Middle Aged, Sperm Count, Spermatozoa, Trichloroethylene, Y Chromosome",
author = "Kurt Rasmussen and S Sabroe and M Wohlert and Ingerslev, {Hans Jakob} and B Kappel and J Nielsen",
year = "1988",
language = "English",
volume = "60",
pages = "419--23",
journal = "International Archives of Occupational and Environmental Health",
issn = "0340-0131",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - A genotoxic study of metal workers exposed to trichloroethylene. Sperm parameters and chromosome aberrations in lymphocytes

AU - Rasmussen, Kurt

AU - Sabroe, S

AU - Wohlert, M

AU - Ingerslev, Hans Jakob

AU - Kappel, B

AU - Nielsen, J

PY - 1988

Y1 - 1988

N2 - Metal workers exposed to trichloroethylene for the degreasing of metals were studied to evaluate the genotoxicity of this exposure. For 15 workers presently exposed to high doses of trichloroethylene there was no difference from unexposed persons with respect to sperm count and morphology, and a small increase of two fluorescent bodies (YFF%) in spermatozoa. In contrast, there was a highly significant increase in frequency of structural aberrations (breaks, gaps, translocation, deletions, inversions) and hyperdiploid cells in cultured lymphocytes from trichloroethylene degreasers. As control groups, physicians from chemically non-exposed surroundings and a concurrently sampled reference from cytogenetic investigations were used. This study indicates positive correlations between exposure to trichloroethylene and somatic chromosome aberrations, whereas no effect on male germ cells could be demonstrated.

AB - Metal workers exposed to trichloroethylene for the degreasing of metals were studied to evaluate the genotoxicity of this exposure. For 15 workers presently exposed to high doses of trichloroethylene there was no difference from unexposed persons with respect to sperm count and morphology, and a small increase of two fluorescent bodies (YFF%) in spermatozoa. In contrast, there was a highly significant increase in frequency of structural aberrations (breaks, gaps, translocation, deletions, inversions) and hyperdiploid cells in cultured lymphocytes from trichloroethylene degreasers. As control groups, physicians from chemically non-exposed surroundings and a concurrently sampled reference from cytogenetic investigations were used. This study indicates positive correlations between exposure to trichloroethylene and somatic chromosome aberrations, whereas no effect on male germ cells could be demonstrated.

KW - Adult

KW - Chromosome Aberrations

KW - Environmental Exposure

KW - Humans

KW - Lymphocytes

KW - Male

KW - Metallurgy

KW - Middle Aged

KW - Sperm Count

KW - Spermatozoa

KW - Trichloroethylene

KW - Y Chromosome

M3 - Journal article

C2 - 3410552

VL - 60

SP - 419

EP - 423

JO - International Archives of Occupational and Environmental Health

JF - International Archives of Occupational and Environmental Health

SN - 0340-0131

IS - 6

ER -