Department of Psychology and Behavioural Sciences

A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Christopher Rayner, Institute of Psychiatry, Psychology and Neuroscience, MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, Great Britain.
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  • Jonathan R I Coleman, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, UK.
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  • Kirstin L Purves, Institute of Psychiatry, Psychology and Neuroscience, MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, Great Britain.
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  • John Hodsoll, Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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  • Kimberley Goldsmith, Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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  • Georg W Alpers, Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
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  • Evelyn Andersson, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
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  • Volker Arolt, Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
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  • Julia Boberg, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
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  • Susan Bögels, Research Institute Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands.
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  • Cathy Creswell, School of Psychology and Clinical Language Sciences, University of Reading
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  • Peter Cooper, School of Psychology and Clinical Language Sciences, University of Reading
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  • Charles Curtis, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, UK.
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  • Jürgen Deckert, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Würzburg, Würzburg, 97078, Germany.
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  • Katharina Domschke, Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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  • Samir El Alaoui, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
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  • Lydia Fehm, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
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  • Thomas Fydrich, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
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  • Alexander L Gerlach, Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.
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  • Anja Grocholewski, Department of Psychology, University of Braunschweig, Braunschweig, Germany.
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  • Kurt Hahlweg, Department of Psychology, University of Braunschweig, Braunschweig, Germany.
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  • Alfons Hamm, Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
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  • Erik Hedman, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
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  • Einar R Heiervang, Division of Mental Health and Addiction, Department of Child and Adolescent Psychiatry, Oslo University Hospital, Oslo, Norway.
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  • Jennifer L Hudson, Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, NSW, Australia.
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  • Peter Jöhren, Mental Health Research and Treatment Center, Ruhr-Universität Bochum, Bochum, Germany.
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  • Robert Keers, Department of Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
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  • Tilo Kircher, Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany; Department of Psychiatry, University of Marburg, Marburg, Germany.
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  • Thomas Lang, Christoph-Dornier-Stiftung für Klinische Psychologie, Institut für Klinische Psychologie und Psychotherapie, Bremen, Germany.
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  • Catharina Lavebratt, Neurogenetics Unit, Center for Molecular Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
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  • Sang-Hyuck Lee, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, UK.
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  • Kathryn J Lester, School of Psychology, University of Sussex, Brighton, UK.
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  • Nils Lindefors, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
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  • Jürgen Margraf, Mental Health Research and Treatment Center, Ruhr-Universität Bochum, Bochum, Germany.
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  • Maaike Nauta, Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, The Netherlands.
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  • Christiane A Pané-Farré, Department of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
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  • Paul Pauli, Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany.
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  • Ronald M Rapee, Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, NSW, Australia.
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  • Andreas Reif, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
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  • Winfried Rief, Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany; Department of Psychiatry, University of Marburg, Marburg, Germany.
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  • Susanna Roberts, Department of Child and Adolescent Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King's College, London, London.
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  • Martin Schalling, Neurogenetics Unit, Center for Molecular Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
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  • Silvia Schneider, Mental Health Research and Treatment Center, Ruhr-Universität Bochum, Bochum, Germany.
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  • Wendy K Silverman, Child Study Center, School of Medicine, Yale University, New Haven, CT, USA.
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  • Andreas Ströhle, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
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  • Tobias Teismann, Mental Health Research and Treatment Center, Ruhr-Universität Bochum, Bochum, Germany.
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  • Mikael Thastum
  • Andre Wannemüller, Dental Clinic Bochum, Bochum, Germany.
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  • Heike Weber, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Würzburg, Würzburg, 97078, Germany.
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  • Hans-Ulrich Wittchen, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
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  • Christiane Wolf, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Würzburg, Würzburg, 97078, Germany.
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  • Christian Rück, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
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  • Gerome Breen, South London and Maudsley NHS Trust, NIHR Biomedical Research Centre for Mental Health, London, UK. gerome.breen@kcl.ac.uk.
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  • Thalia C Eley, South London and Maudsley NHS Trust, NIHR Biomedical Research Centre for Mental Health, London, UK. thalia.eley@kcl.ac.uk.

Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (rg ≈ 1). Cognitive behavioural therapy is a leading evidence-based treatment but has variable outcomes. Currently, there are no strong predictors of outcome. Therapygenetics research aims to identify genetic predictors of prognosis following therapy. We performed genome-wide association meta-analyses of symptoms following cognitive behavioural therapy in adults with anxiety disorders (n = 972), adults with major depressive disorder (n = 832) and children with anxiety disorders (n = 920; meta-analysis n = 2724). We estimated the variance in therapy outcomes that could be explained by common genetic variants (h2SNP) and polygenic scoring was used to examine genetic associations between therapy outcomes and psychopathology, personality and learning. No single nucleotide polymorphisms were strongly associated with treatment outcomes. No significant estimate of h2SNP could be obtained, suggesting the heritability of therapy outcome is smaller than our analysis was powered to detect. Polygenic scoring failed to detect genetic overlap between therapy outcome and psychopathology, personality or learning. This study is the largest therapygenetics study to date. Results are consistent with previous, similarly powered genome-wide association studies of complex traits.

Original languageEnglish
Article number150
JournalTranslational Psychiatry
Volume9
Issue1
Number of pages13
ISSN2158-3188
DOIs
Publication statusPublished - May 2019

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