A genome-wide association study of social trust in 33,882 Danish blood donors

Palle Duun Rohde; Mette Nyegaard; Christian Erikstrup; DBDS Genomic Consortium; Katrine Kaspersen; Jens Kjærgaard Boldsen; Lotte Aas Hindhede

doi:10.1038/s41598-024-51636-0

A genome-wide association study of social trust in 33,882 Danish blood donors

Palle Duun Rohde, Mette Nyegaard, Christian Erikstrup, DBDS Genomic Consortium, Katrine Kaspersen, Jens Kjærgaard Boldsen, Lotte Aas Hindhede

Department of Clinical Medicine - Department of Clinical Immunology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

Abstract

Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

Original language	English
Article number	1402
Journal	Scientific Reports
Volume	14
Issue	1
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-024-51636-0
Publication status	Published - 16 Jan 2024

Keywords

Blood Donors
Denmark
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Phenotype
Polymorphism, Single Nucleotide
Trust

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title = "A genome-wide association study of social trust in 33,882 Danish blood donors",

abstract = "Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.",

keywords = "Blood Donors, Denmark, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide, Trust",

author = "Sequeros, {Celia Burgos} and Hansen, {Thomas Folkmann} and David Westergaard and Ioannis Louloudis and Sebastian Kalamajski and Timo R{\"o}der and Rohde, {Palle Duun} and Michael Schwinn and Clemmensen, {Line Harder} and Maria Didriksen and Mette Nyegaard and Henrik Hjalgrim and Nielsen, {Kaspar Ren{\'e}} and Bruun, {Mie Topholm} and Ostrowski, {Sisse Rye} and Christian Erikstrup and Susan Mikkelsen and Erik S{\o}rensen and {DBDS Genomic Consortium} and S{\o}ren Brunak and Karina Banasik and Giordano, {Giuseppe Nicola} and Kjerulff, {Bertram Dalskov} and Katrine Kaspersen and Boldsen, {Jens Kj{\ae}rgaard} and Hindhede, {Lotte Aas}",

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AU - Sequeros, Celia Burgos

AU - Hansen, Thomas Folkmann

AU - Westergaard, David

AU - Louloudis, Ioannis

AU - Kalamajski, Sebastian

AU - Röder, Timo

AU - Rohde, Palle Duun

AU - Schwinn, Michael

AU - Clemmensen, Line Harder

AU - Didriksen, Maria

AU - Nyegaard, Mette

AU - Hjalgrim, Henrik

AU - Nielsen, Kaspar René

AU - Bruun, Mie Topholm

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

AU - Mikkelsen, Susan

AU - Sørensen, Erik

AU - DBDS Genomic Consortium

AU - Brunak, Søren

AU - Banasik, Karina

AU - Giordano, Giuseppe Nicola

AU - Kjerulff, Bertram Dalskov

AU - Kaspersen, Katrine

AU - Boldsen, Jens Kjærgaard

AU - Hindhede, Lotte Aas

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N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

KW - Blood Donors

KW - Denmark

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Trust

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DO - 10.1038/s41598-024-51636-0

M3 - Journal article

C2 - 38228779

AN - SCOPUS:85182480285

SN - 2045-2322

VL - 14

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 1402

ER -

A genome-wide association study of social trust in 33,882 Danish blood donors

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Keywords

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