A genome and gene catalog of glacier microbiomes

Yongqin Liu; Mukan Ji; Tao Yu; Julian Zaugg; Alexandre M. Anesio; Zhihao Zhang; Songnian Hu; Philip Hugenholtz; Keshao Liu; Pengfei Liu; Yuying Chen; Yingfeng Luo; Tandong Yao

doi:10.1038/s41587-022-01367-2

A genome and gene catalog of glacier microbiomes

Yongqin Liu^*, Mukan Ji, Tao Yu, Julian Zaugg, Alexandre M. Anesio, Zhihao Zhang, Songnian Hu, Philip Hugenholtz, Keshao Liu, Pengfei Liu, Yuying Chen, Yingfeng Luo^*, Tandong Yao

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-latitude glaciers and is particularly vulnerable to global warming. By sequencing 85 metagenomes and 883 cultured isolates from 21 Tibetan glaciers covering snow, ice and cryoconite habitats, we present a specialized glacier microbial genome and gene catalog to archive glacial genomic and functional diversity. This comprehensive Tibetan Glacier Genome and Gene (TG2G) catalog includes 883 genomes and 2,358 metagenome-assembled genomes, which represent 968 candidate species spanning 30 phyla. The catalog also contains over 25 million non-redundant protein-encoding genes, the utility of which is demonstrated by the exploration of secondary metabolite biosynthetic potentials, virulence factor identification and global glacier metagenome comparison. The TG2G catalog is a valuable resource that enables enhanced understanding of the structure and functions of Tibetan glacial microbiomes.

Original language	English
Journal	Nature Biotechnology
Volume	40
Issue	9
Pages (from-to)	1341-1348
Number of pages	8
ISSN	1087-0156
DOIs	https://doi.org/10.1038/s41587-022-01367-2
Publication status	Published - Sept 2022

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title = "A genome and gene catalog of glacier microbiomes",

abstract = "Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-latitude glaciers and is particularly vulnerable to global warming. By sequencing 85 metagenomes and 883 cultured isolates from 21 Tibetan glaciers covering snow, ice and cryoconite habitats, we present a specialized glacier microbial genome and gene catalog to archive glacial genomic and functional diversity. This comprehensive Tibetan Glacier Genome and Gene (TG2G) catalog includes 883 genomes and 2,358 metagenome-assembled genomes, which represent 968 candidate species spanning 30 phyla. The catalog also contains over 25 million non-redundant protein-encoding genes, the utility of which is demonstrated by the exploration of secondary metabolite biosynthetic potentials, virulence factor identification and global glacier metagenome comparison. The TG2G catalog is a valuable resource that enables enhanced understanding of the structure and functions of Tibetan glacial microbiomes.",

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note = "Funding Information: This study was supported by the Second Tibetan Plateau Scientific Expedition and Research Program (STEP) 2019QZKK0503 (Y. Liu and K.L.) and 2021QZKK0100 (P.L., Y. Luo and T. Yu); the National Key Research and Development Plans 2019YFC1509103 (Y. Liu) and 2021YFC2300904 (M.J.); and the Major Research Plan of the National Natural Science Foundation of China 91851207 (Y. Liu and Y.C.). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",

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AU - Yu, Tao

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AU - Zhang, Zhihao

AU - Hu, Songnian

AU - Hugenholtz, Philip

AU - Liu, Keshao

AU - Liu, Pengfei

AU - Chen, Yuying

AU - Luo, Yingfeng

AU - Yao, Tandong

N1 - Funding Information: This study was supported by the Second Tibetan Plateau Scientific Expedition and Research Program (STEP) 2019QZKK0503 (Y. Liu and K.L.) and 2021QZKK0100 (P.L., Y. Luo and T. Yu); the National Key Research and Development Plans 2019YFC1509103 (Y. Liu) and 2021YFC2300904 (M.J.); and the Major Research Plan of the National Natural Science Foundation of China 91851207 (Y. Liu and Y.C.). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.

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N2 - Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-latitude glaciers and is particularly vulnerable to global warming. By sequencing 85 metagenomes and 883 cultured isolates from 21 Tibetan glaciers covering snow, ice and cryoconite habitats, we present a specialized glacier microbial genome and gene catalog to archive glacial genomic and functional diversity. This comprehensive Tibetan Glacier Genome and Gene (TG2G) catalog includes 883 genomes and 2,358 metagenome-assembled genomes, which represent 968 candidate species spanning 30 phyla. The catalog also contains over 25 million non-redundant protein-encoding genes, the utility of which is demonstrated by the exploration of secondary metabolite biosynthetic potentials, virulence factor identification and global glacier metagenome comparison. The TG2G catalog is a valuable resource that enables enhanced understanding of the structure and functions of Tibetan glacial microbiomes.

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A genome and gene catalog of glacier microbiomes

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