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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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  • William Garland
  • Itys Comet, University of Copenhagen
  • ,
  • Mengjun Wu, University of Copenhagen
  • ,
  • Aliaksandra Radzisheuskaya, University of Copenhagen, Memorial Sloan-Kettering Cancer Center
  • ,
  • Leonor Rib, University of Copenhagen
  • ,
  • Kristoffer Vitting-Seerup, University of Copenhagen
  • ,
  • Marta Lloret-Llinares
  • ,
  • Albin Sandelin, University of Copenhagen
  • ,
  • Kristian Helin, University of Copenhagen, Memorial Sloan-Kettering Cancer Center
  • ,
  • Torben Heick Jensen

ZFC3H1 targets pA+ RNA for decay by the nuclear RNA exosome. Garland et al. report a disruptive relationship between excess RNA and PRC2 upon depletion of ZFC3H1 in mouse ESCs. In such conditions, RNA is bound by PRC2 components, which show reduced binding to chromatin and fellow PRC2 proteins.

Original languageEnglish
JournalCell Reports
Volume29
Issue7
Pages (from-to)1800-1811.e6
Number of pages18
ISSN2211-1247
DOIs
Publication statusPublished - Nov 2019

Bibliographical note

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

    Research areas

  • chromatin, H3K27 methylation, nuclear RNA decay, PAXT, PRC2, RNA exosome, stem cell regulation, READ ALIGNMENT, DEVELOPMENTAL REGULATORS, CHROMATIN, DNA METHYLATION, EXOSOME, PLURIPOTENCY, GENE-EXPRESSION, DIFFERENTIAL EXPRESSION ANALYSIS, PROTEIN EED, RNA, Nuclear/genetics, Polycomb Repressive Complex 2/genetics, Transcription, Genetic, Transcription Factors/genetics, RNA Stability, Mouse Embryonic Stem Cells/cytology, Mice, Knockout, Animals, Chromatin/genetics, Mice

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