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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • William Garland
  • Itys Comet, Københavns Universitet
  • ,
  • Mengjun Wu, Københavns Universitet
  • ,
  • Aliaksandra Radzisheuskaya, Københavns Universitet, Memorial Sloan-Kettering Cancer Center
  • ,
  • Leonor Rib, Københavns Universitet
  • ,
  • Kristoffer Vitting-Seerup, Københavns Universitet
  • ,
  • Marta Lloret-Llinares
  • ,
  • Albin Sandelin, Københavns Universitet
  • ,
  • Kristian Helin, Københavns Universitet, Memorial Sloan-Kettering Cancer Center
  • ,
  • Torben Heick Jensen

ZFC3H1 targets pA+ RNA for decay by the nuclear RNA exosome. Garland et al. report a disruptive relationship between excess RNA and PRC2 upon depletion of ZFC3H1 in mouse ESCs. In such conditions, RNA is bound by PRC2 components, which show reduced binding to chromatin and fellow PRC2 proteins.

Original languageEnglish
JournalCell Reports
Pages (from-to)1800-1811.e6
Number of pages19
Publication statusPublished - Nov 2019

    Research areas

  • chromatin, H3K27 methylation, nuclear RNA decay, PAXT, PRC2, RNA exosome, stem cell regulation

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