A fast SALLE GC–MS/MS multi-analyte method for the determination of 75 food packaging substances in food simulants

Emmanouil D. Tsochatzis; Joao Alberto Lopes; Helen Gika; Trine Kastrup Dalsgaard; Georgios Theodoridis

doi:10.1016/j.foodchem.2021.129998

A fast SALLE GC–MS/MS multi-analyte method for the determination of 75 food packaging substances in food simulants

Emmanouil D. Tsochatzis^*, Joao Alberto Lopes, Helen Gika, Trine Kastrup Dalsgaard, Georgios Theodoridis

^*Corresponding author for this work

Department of Food Science - Food Chemistry

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

A simple and fast method was developed for the simultaneous determination of 75 plastic food contact material (FCM) in liquid food simulants, at levels of a few ng g⁻¹. The method employs an optimised salt-assisted liquid–liquid extraction for all EU-regulated ethanol/H₂O food simulants, in the presence of 10% NaCl (simulants A and C) or 5% NaCl (simulant D1), and dichloromethane as the extracting solvent. Gas chromatography with triple-quad MS operating in multiple reaction monitoring acquisition was used, applying isotope dilution with selected deuterated compounds. Adequate sensitivity was demonstrated for all analytes. The results also showed sufficient accuracy for the majority of substances, with recoveries of 70–120% and repeatability (expressed as relative standard deviations, RSDs) smaller than 15%. The method was applied to the analysis of FCM multilayer items after undergoing migration testing according to the specifications of the current EU legislation in force.

Original language	English
Article number	129998
Journal	Food Chemistry
Volume	361
ISSN	0308-8146
DOIs	https://doi.org/10.1016/j.foodchem.2021.129998
Publication status	Published - 1 Nov 2021

Keywords

GC–MS/MS
Internal standard correction (deuterated standards)
Migration in food simulants
Multi-analyte method
Salt-assisted liquid–liquid extraction

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10.1016/j.foodchem.2021.129998

1-s2.0-S0308814621010049-mainFinal published version, 1.35 MBLicence: CC BY

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title = "A fast SALLE GC–MS/MS multi-analyte method for the determination of 75 food packaging substances in food simulants",

abstract = "A simple and fast method was developed for the simultaneous determination of 75 plastic food contact material (FCM) in liquid food simulants, at levels of a few ng g−1. The method employs an optimised salt-assisted liquid–liquid extraction for all EU-regulated ethanol/H2O food simulants, in the presence of 10% NaCl (simulants A and C) or 5% NaCl (simulant D1), and dichloromethane as the extracting solvent. Gas chromatography with triple-quad MS operating in multiple reaction monitoring acquisition was used, applying isotope dilution with selected deuterated compounds. Adequate sensitivity was demonstrated for all analytes. The results also showed sufficient accuracy for the majority of substances, with recoveries of 70–120% and repeatability (expressed as relative standard deviations, RSDs) smaller than 15%. The method was applied to the analysis of FCM multilayer items after undergoing migration testing according to the specifications of the current EU legislation in force.",

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year = "2021",

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doi = "10.1016/j.foodchem.2021.129998",

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A fast SALLE GC–MS/MS multi-analyte method for the determination of 75 food packaging substances in food simulants. / Tsochatzis, Emmanouil D.; Lopes, Joao Alberto; Gika, Helen et al.
In: Food Chemistry, Vol. 361, 129998, 01.11.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Tsochatzis, Emmanouil D.

AU - Lopes, Joao Alberto

AU - Gika, Helen

AU - Dalsgaard, Trine Kastrup

AU - Theodoridis, Georgios

PY - 2021/11/1

Y1 - 2021/11/1

N2 - A simple and fast method was developed for the simultaneous determination of 75 plastic food contact material (FCM) in liquid food simulants, at levels of a few ng g−1. The method employs an optimised salt-assisted liquid–liquid extraction for all EU-regulated ethanol/H2O food simulants, in the presence of 10% NaCl (simulants A and C) or 5% NaCl (simulant D1), and dichloromethane as the extracting solvent. Gas chromatography with triple-quad MS operating in multiple reaction monitoring acquisition was used, applying isotope dilution with selected deuterated compounds. Adequate sensitivity was demonstrated for all analytes. The results also showed sufficient accuracy for the majority of substances, with recoveries of 70–120% and repeatability (expressed as relative standard deviations, RSDs) smaller than 15%. The method was applied to the analysis of FCM multilayer items after undergoing migration testing according to the specifications of the current EU legislation in force.

AB - A simple and fast method was developed for the simultaneous determination of 75 plastic food contact material (FCM) in liquid food simulants, at levels of a few ng g−1. The method employs an optimised salt-assisted liquid–liquid extraction for all EU-regulated ethanol/H2O food simulants, in the presence of 10% NaCl (simulants A and C) or 5% NaCl (simulant D1), and dichloromethane as the extracting solvent. Gas chromatography with triple-quad MS operating in multiple reaction monitoring acquisition was used, applying isotope dilution with selected deuterated compounds. Adequate sensitivity was demonstrated for all analytes. The results also showed sufficient accuracy for the majority of substances, with recoveries of 70–120% and repeatability (expressed as relative standard deviations, RSDs) smaller than 15%. The method was applied to the analysis of FCM multilayer items after undergoing migration testing according to the specifications of the current EU legislation in force.

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A fast SALLE GC–MS/MS multi-analyte method for the determination of 75 food packaging substances in food simulants

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