A fast SALLE GC–MS/MS multi-analyte method for the determination of 75 food packaging substances in food simulants

Emmanouil D. Tsochatzis*, Joao Alberto Lopes, Helen Gika, Trine Kastrup Dalsgaard, Georgios Theodoridis

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

44 Downloads (Pure)

Abstract

A simple and fast method was developed for the simultaneous determination of 75 plastic food contact material (FCM) in liquid food simulants, at levels of a few ng g−1. The method employs an optimised salt-assisted liquid–liquid extraction for all EU-regulated ethanol/H2O food simulants, in the presence of 10% NaCl (simulants A and C) or 5% NaCl (simulant D1), and dichloromethane as the extracting solvent. Gas chromatography with triple-quad MS operating in multiple reaction monitoring acquisition was used, applying isotope dilution with selected deuterated compounds. Adequate sensitivity was demonstrated for all analytes. The results also showed sufficient accuracy for the majority of substances, with recoveries of 70–120% and repeatability (expressed as relative standard deviations, RSDs) smaller than 15%. The method was applied to the analysis of FCM multilayer items after undergoing migration testing according to the specifications of the current EU legislation in force.

Original languageEnglish
Article number129998
JournalFood Chemistry
Volume361
ISSN0308-8146
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • GC–MS/MS
  • Internal standard correction (deuterated standards)
  • Migration in food simulants
  • Multi-analyte method
  • Salt-assisted liquid–liquid extraction

Fingerprint

Dive into the research topics of 'A fast SALLE GC–MS/MS multi-analyte method for the determination of 75 food packaging substances in food simulants'. Together they form a unique fingerprint.

Cite this