A Danish Twin Study of Schizophrenia Liability: Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons

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A Danish Twin Study of Schizophrenia Liability : Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons. / Kläning, Ulla; Trumbetta, Susan L; Gottesman, Irving I; Skytthe, Axel; Kyvik, Kirsten O; Bertelsen, Aksel.

In: Behavior Genetics, Vol. 46, No. 2, 03.2016, p. 193-204.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Kläning, U, Trumbetta, SL, Gottesman, II, Skytthe, A, Kyvik, KO & Bertelsen, A 2016, 'A Danish Twin Study of Schizophrenia Liability: Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons', Behavior Genetics, vol. 46, no. 2, pp. 193-204. https://doi.org/10.1007/s10519-015-9765-z

APA

Kläning, U., Trumbetta, S. L., Gottesman, I. I., Skytthe, A., Kyvik, K. O., & Bertelsen, A. (2016). A Danish Twin Study of Schizophrenia Liability: Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons. Behavior Genetics, 46(2), 193-204. https://doi.org/10.1007/s10519-015-9765-z

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Author

Kläning, Ulla ; Trumbetta, Susan L ; Gottesman, Irving I ; Skytthe, Axel ; Kyvik, Kirsten O ; Bertelsen, Aksel. / A Danish Twin Study of Schizophrenia Liability : Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons. In: Behavior Genetics. 2016 ; Vol. 46, No. 2. pp. 193-204.

Bibtex

@article{4f6c0d2741a2464c96baa5d27f6fcdd8,
title = "A Danish Twin Study of Schizophrenia Liability: Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons",
abstract = "We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other psychotic disorders but much less so for the broader category of psychiatric disorders in general. We also observed a marginally significant decline in schizophrenia variance attributable to environmental factors over successive Western European cohorts, consistent perhaps with improvements in diagnosis and in prenatal and perinatal care and with a secular decline in the prevalence of schizophrenia in that region.",
author = "Ulla Kl{\"a}ning and Trumbetta, {Susan L} and Gottesman, {Irving I} and Axel Skytthe and Kyvik, {Kirsten O} and Aksel Bertelsen",
year = "2016",
month = "3",
doi = "10.1007/s10519-015-9765-z",
language = "English",
volume = "46",
pages = "193--204",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York LLC",
number = "2",

}

RIS

TY - JOUR

T1 - A Danish Twin Study of Schizophrenia Liability

T2 - Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons

AU - Kläning, Ulla

AU - Trumbetta, Susan L

AU - Gottesman, Irving I

AU - Skytthe, Axel

AU - Kyvik, Kirsten O

AU - Bertelsen, Aksel

PY - 2016/3

Y1 - 2016/3

N2 - We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other psychotic disorders but much less so for the broader category of psychiatric disorders in general. We also observed a marginally significant decline in schizophrenia variance attributable to environmental factors over successive Western European cohorts, consistent perhaps with improvements in diagnosis and in prenatal and perinatal care and with a secular decline in the prevalence of schizophrenia in that region.

AB - We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other psychotic disorders but much less so for the broader category of psychiatric disorders in general. We also observed a marginally significant decline in schizophrenia variance attributable to environmental factors over successive Western European cohorts, consistent perhaps with improvements in diagnosis and in prenatal and perinatal care and with a secular decline in the prevalence of schizophrenia in that region.

U2 - 10.1007/s10519-015-9765-z

DO - 10.1007/s10519-015-9765-z

M3 - Journal article

C2 - 26538243

VL - 46

SP - 193

EP - 204

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 2

ER -