A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

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A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI. / Nielsen, Birgit Marie; Nielsen, Marie M; Jakobsen, Marianne Uhre; Nielsen, Carina J; Holst, Claus; Larsen, Thomas Meinert; Bendsen, Nathalie Tommerup; Bysted, Anette; Leth, Torben; Hougaard, David M; Skogstrand, Kristin; Astrup, Arne; Sørensen, Thorkild I.A.; Jess, Tine.

In: British Journal of Nutrition, Vol. 106, No. 8, 2011, p. 1245-52.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Nielsen, BM, Nielsen, MM, Jakobsen, MU, Nielsen, CJ, Holst, C, Larsen, TM, Bendsen, NT, Bysted, A, Leth, T, Hougaard, DM, Skogstrand, K, Astrup, A, Sørensen, TIA & Jess, T 2011, 'A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI', British Journal of Nutrition, vol. 106, no. 8, pp. 1245-52. https://doi.org/10.1017/S0007114511001474

APA

Nielsen, B. M., Nielsen, M. M., Jakobsen, M. U., Nielsen, C. J., Holst, C., Larsen, T. M., Bendsen, N. T., Bysted, A., Leth, T., Hougaard, D. M., Skogstrand, K., Astrup, A., Sørensen, T. I. A., & Jess, T. (2011). A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI. British Journal of Nutrition, 106(8), 1245-52. https://doi.org/10.1017/S0007114511001474

CBE

Nielsen BM, Nielsen MM, Jakobsen MU, Nielsen CJ, Holst C, Larsen TM, Bendsen NT, Bysted A, Leth T, Hougaard DM, Skogstrand K, Astrup A, Sørensen TIA, Jess T. 2011. A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI. British Journal of Nutrition. 106(8):1245-52. https://doi.org/10.1017/S0007114511001474

MLA

Vancouver

Nielsen BM, Nielsen MM, Jakobsen MU, Nielsen CJ, Holst C, Larsen TM et al. A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI. British Journal of Nutrition. 2011;106(8):1245-52. https://doi.org/10.1017/S0007114511001474

Author

Nielsen, Birgit Marie ; Nielsen, Marie M ; Jakobsen, Marianne Uhre ; Nielsen, Carina J ; Holst, Claus ; Larsen, Thomas Meinert ; Bendsen, Nathalie Tommerup ; Bysted, Anette ; Leth, Torben ; Hougaard, David M ; Skogstrand, Kristin ; Astrup, Arne ; Sørensen, Thorkild I.A. ; Jess, Tine. / A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI. In: British Journal of Nutrition. 2011 ; Vol. 106, No. 8. pp. 1245-52.

Bibtex

@article{25fc7bfab94d4a0bbb70e49934a4b589,
title = "A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI",
abstract = "Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m(2). Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake.",
author = "Nielsen, {Birgit Marie} and Nielsen, {Marie M} and Jakobsen, {Marianne Uhre} and Nielsen, {Carina J} and Claus Holst and Larsen, {Thomas Meinert} and Bendsen, {Nathalie Tommerup} and Anette Bysted and Torben Leth and Hougaard, {David M} and Kristin Skogstrand and Arne Astrup and S{\o}rensen, {Thorkild I.A.} and Tine Jess",
year = "2011",
doi = "10.1017/S0007114511001474",
language = "English",
volume = "106",
pages = "1245--52",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "8",

}

RIS

TY - JOUR

T1 - A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

AU - Nielsen, Birgit Marie

AU - Nielsen, Marie M

AU - Jakobsen, Marianne Uhre

AU - Nielsen, Carina J

AU - Holst, Claus

AU - Larsen, Thomas Meinert

AU - Bendsen, Nathalie Tommerup

AU - Bysted, Anette

AU - Leth, Torben

AU - Hougaard, David M

AU - Skogstrand, Kristin

AU - Astrup, Arne

AU - Sørensen, Thorkild I.A.

AU - Jess, Tine

PY - 2011

Y1 - 2011

N2 - Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m(2). Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake.

AB - Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m(2). Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake.

U2 - 10.1017/S0007114511001474

DO - 10.1017/S0007114511001474

M3 - Journal article

C2 - 21736833

VL - 106

SP - 1245

EP - 1252

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 8

ER -