A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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  • Francesca L Crowe, Denmark
  • Timothy J Key, Denmark
  • Naomi E Allen, Denmark
  • Paul N Appleby, Denmark
  • Kim Overvad
  • Henning Grønbæk
  • Anne Tjønneland, Denmark
  • Jytte Halkjær, Denmark
  • Laure Dossus, Denmark
  • Heiner Boeing, Denmark
  • Janine Kröger, Denmark
  • Antonia Trichopoulou, Denmark
  • Dimosthenis Zylis, Denmark
  • Dimitrios Trichopoulos, Denmark
  • Marie-Christine Boutron-Ruault, Denmark
  • Blandine de Lauzon-Guillain, Denmark
  • Françoise Clavel-Chapelon, Denmark
  • Domenico Palli, Denmark
  • Franco Berrino, Denmark
  • Salvatore Panico, Denmark
  • Rosario Tumino, Denmark
  • Carlotta Sacerdote, Denmark
  • H Bas Bueno-de-Mesquita, Denmark
  • Carla H van Gils, Denmark
  • Petra H M Peeters, Denmark
  • Inger T Gram, Denmark
  • Laudina Rodríguez, Denmark
  • Paula Jakszyn, Denmark
  • Esther Molina-Montes, Denmark
  • Carmen Navarro, Denmark
  • Aurelio Barricarte, Denmark
  • Nerea Larrañaga, Denmark
  • Kay-Tee Khaw, Denmark
  • Sheila Rodwell, Denmark
  • Sabina Rinaldi, Denmark
  • Nadia Slimani, Denmark
  • Teresa Norat, Denmark
  • Valentina Gallo, Denmark
  • Elio Riboli, Denmark
  • Rudolf Kaaks, Denmark
Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: - 0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.
Original languageEnglish
JournalAnnals of Human Biology
Volume38
Issue2
Pages (from-to)194-202
ISSN0301-4460
DOIs
Publication statusPublished - Mar 2011

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