A combination of chitooligosaccharide and lipochitooligosaccharide recognition promotes arbuscular mycorrhizal associations in Medicago truncatula

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  • Feng Feng, Sainsbury Laboratory Cambridge University
  • ,
  • Jongho Sun, Sainsbury Laboratory Cambridge University
  • ,
  • Guru V. Radhakrishnan, John Innes Centre
  • ,
  • Tak Lee, Sainsbury Laboratory Cambridge University
  • ,
  • Zoltán Bozsóki
  • ,
  • Sébastien Fort, Universite Grenoble Alpes
  • ,
  • Aleksander Gavrin, Sainsbury Laboratory Cambridge University
  • ,
  • Kira Gysel
  • Mikkel B. Thygesen, Københavns Universitet
  • ,
  • Kasper Røjkjær Andersen
  • Simona Radutoiu
  • Jens Stougaard
  • Giles E.D. Oldroyd, Sainsbury Laboratory Cambridge University

Plants associate with beneficial arbuscular mycorrhizal fungi facilitating nutrient acquisition. Arbuscular mycorrhizal fungi produce chitooligosaccharides (COs) and lipo-chitooligosaccharides (LCOs), that promote symbiosis signalling with resultant oscillations in nuclear-associated calcium. The activation of symbiosis signalling must be balanced with activation of immunity signalling, which in fungal interactions is promoted by COs resulting from the chitinaceous fungal cell wall. Here we demonstrate that COs ranging from CO4-CO8 can induce symbiosis signalling in Medicago truncatula. CO perception is a function of the receptor-like kinases MtCERK1 and LYR4, that activate both immunity and symbiosis signalling. A combination of LCOs and COs act synergistically to enhance symbiosis signalling and suppress immunity signalling and receptors involved in both CO and LCO perception are necessary for mycorrhizal establishment. We conclude that LCOs, when present in a mix with COs, drive a symbiotic outcome and this mix of signals is essential for arbuscular mycorrhizal establishment.

Original languageEnglish
Article number5047
JournalNature Communications
Volume10
Issue1
Number of pages12
ISSN2041-1723
DOIs
Publication statusPublished - 2019

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