A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration

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A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration. / Su, Yingchun; Taskin, Mehmet Berat; Dong, MD; Han, Xiaojun; Besenbacher, Flemming; Chen, Menglin.

In: Materials Chemistry Frontiers, Vol. 4, No. 7, 01.07.2020, p. 2149-2156.

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Su, Yingchun ; Taskin, Mehmet Berat ; Dong, MD ; Han, Xiaojun ; Besenbacher, Flemming ; Chen, Menglin. / A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration. In: Materials Chemistry Frontiers. 2020 ; Vol. 4, No. 7. pp. 2149-2156.

Bibtex

@article{9d3bc318d22b4cf4ac0debd982fc7e27,
title = "A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration",
abstract = "A helical perversion as a singularity structure is widely seen in nature, such as a climbing plant tendril, which is referred to as a kinked state connecting two helices with opposite chirality. Although previous macroscale elastic bistrip systems have been used to fabricate multiple helix-perversion structures, it is still challenging to obtain multi-perversions on the microscale. Herein, we have for the first time, discovered an interesting phenomenon when PCL microcoils were assembled on PEO/PCL microstems using wet, side-by-side electrospinning which combines side-by-side electrospinning with coagulation bath collection. Such side-by-side electrospun Janus microfibers, due to the mismatch strain between the two jets in the coagulation bath, are transformed into 3D multi-helix-perversion microstructures through self-scrolling. On the 3D multi-helix-perversion microstructures, the growth of HUVECs (human umbilical vein endothelial cells) are observed with a preferential cell distribution of around 86% on the PCL microcoils. Simultaneously, higher focal adhesion, enhanced cell proliferation and elongation are also exhibited by the PCL microcoils, leading to a distinctive 3D Janus cellular pattern. Such novel 3D multi-helix-perversion microstructures have great potential in 3D Janus biomaterials for adjustable cell patterning.",
keywords = "EXPRESSION, FABRICATION, FIBERS, HYDROGEL, IMPROVES, MECHANICS, SCAFFOLDS, SHAPE",
author = "Yingchun Su and Taskin, {Mehmet Berat} and MD Dong and Xiaojun Han and Flemming Besenbacher and Menglin Chen",
year = "2020",
month = jul,
day = "1",
doi = "10.1039/D0QM00125B",
language = "English",
volume = "4",
pages = "2149--2156",
journal = "Materials Chemistry Frontiers",
publisher = "royal society of chemistry",
number = "7",

}

RIS

TY - JOUR

T1 - A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration

AU - Su, Yingchun

AU - Taskin, Mehmet Berat

AU - Dong, MD

AU - Han, Xiaojun

AU - Besenbacher, Flemming

AU - Chen, Menglin

PY - 2020/7/1

Y1 - 2020/7/1

N2 - A helical perversion as a singularity structure is widely seen in nature, such as a climbing plant tendril, which is referred to as a kinked state connecting two helices with opposite chirality. Although previous macroscale elastic bistrip systems have been used to fabricate multiple helix-perversion structures, it is still challenging to obtain multi-perversions on the microscale. Herein, we have for the first time, discovered an interesting phenomenon when PCL microcoils were assembled on PEO/PCL microstems using wet, side-by-side electrospinning which combines side-by-side electrospinning with coagulation bath collection. Such side-by-side electrospun Janus microfibers, due to the mismatch strain between the two jets in the coagulation bath, are transformed into 3D multi-helix-perversion microstructures through self-scrolling. On the 3D multi-helix-perversion microstructures, the growth of HUVECs (human umbilical vein endothelial cells) are observed with a preferential cell distribution of around 86% on the PCL microcoils. Simultaneously, higher focal adhesion, enhanced cell proliferation and elongation are also exhibited by the PCL microcoils, leading to a distinctive 3D Janus cellular pattern. Such novel 3D multi-helix-perversion microstructures have great potential in 3D Janus biomaterials for adjustable cell patterning.

AB - A helical perversion as a singularity structure is widely seen in nature, such as a climbing plant tendril, which is referred to as a kinked state connecting two helices with opposite chirality. Although previous macroscale elastic bistrip systems have been used to fabricate multiple helix-perversion structures, it is still challenging to obtain multi-perversions on the microscale. Herein, we have for the first time, discovered an interesting phenomenon when PCL microcoils were assembled on PEO/PCL microstems using wet, side-by-side electrospinning which combines side-by-side electrospinning with coagulation bath collection. Such side-by-side electrospun Janus microfibers, due to the mismatch strain between the two jets in the coagulation bath, are transformed into 3D multi-helix-perversion microstructures through self-scrolling. On the 3D multi-helix-perversion microstructures, the growth of HUVECs (human umbilical vein endothelial cells) are observed with a preferential cell distribution of around 86% on the PCL microcoils. Simultaneously, higher focal adhesion, enhanced cell proliferation and elongation are also exhibited by the PCL microcoils, leading to a distinctive 3D Janus cellular pattern. Such novel 3D multi-helix-perversion microstructures have great potential in 3D Janus biomaterials for adjustable cell patterning.

KW - EXPRESSION

KW - FABRICATION

KW - FIBERS

KW - HYDROGEL

KW - IMPROVES

KW - MECHANICS

KW - SCAFFOLDS

KW - SHAPE

U2 - 10.1039/D0QM00125B

DO - 10.1039/D0QM00125B

M3 - Journal article

VL - 4

SP - 2149

EP - 2156

JO - Materials Chemistry Frontiers

JF - Materials Chemistry Frontiers

IS - 7

ER -