A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: Additional evidence for the common occurrence of balancing selection in livestock

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  • Naveen Kumar Kadri, Denmark
  • Goutam Sahana
  • Carole Charlier, Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Belgium
  • Terhi Iso-Touru, MTT Agrifood Research Finland, Biotechnology and Food Research, Finland
  • Bernt Guldbrandtsen, Denmark
  • Latifa Karim, Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Belgium
  • Ulrik Sander Nielsen, Danish Agricultural Advisory Service, Denmark
  • Frank Panitz
  • Gert Pedersen Aamand, Nordic Cattle Genetic Evaluation, Denmark
  • Nina Schulman, MTT Agrifood Research Finland, Biotechnology and Food Research, Finland
  • Michel Georges, Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Belgium
  • Johanna Vilkki, MTT Agrifood Research Finland, Biotechnology and Food Research, Finland
  • Mogens Sandø Lund
  • Tom Druet, Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Belgium
In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has concomitantly severely declined. It is generally assumed that this reduction is primarily due to the negative energy balance of high-producing cows at the peak of lactation. We herein describe the fine-mapping of a major fertility QTL in Nordic Red cattle, and identify a 660-kb deletion encompassing four genes as the causative variant. We show that the deletion is a recessive embryonically lethal mutation. This probably results from the loss of RNASEH2B, which is known to cause embryonic death in mice. Despite its dramatic effect on fertility, 13%, 23% and 32% of the animals carry the deletion in Danish, Swedish and Finnish Red Cattle, respectively. To explain this, we searched for favorable effects on other traits and found that the deletion has strong positive effects on milk yield. This study demonstrates that embryonic lethal mutations account for a non-negligible fraction of the decline in fertility of domestic cattle, and that associated positive effects on milk yield may account for part of the negative genetic correlation. Our study adds to the evidence that structural variants contribute to animal phenotypic variation, and that balancing selection might be more common in livestock species than previously appreciated.
Original languageEnglish
Article numbere1004049
JournalP L o S Genetics
Volume10
Issue1
Pages (from-to)1-11
Number of pages11
ISSN1553-7390
DOIs
Publication statusPublished - 2 Jan 2014

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