A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock

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  • Naveen Kumar Kadri, University of Liège, Liège, Belgium, Denmark
  • Goutam Sahana
  • Carole Charlier, University of Liège, Liège, Belgium, Belgium
  • Terhi Iso-Touru, MTT Agrifood Research Finland, Jokioinen, Finland
  • Bernt Guldbrandtsen, Denmark
  • Latifa Karim, University of Liège, Liège, Belgium, Belgium
  • Ulrik Sander Nielsen, Danish Agricultural Advisory Service, Aarhus, Denmark, Denmark
  • Frank Panitz
  • Gert Aamand Pedersen, Nordic Cattle Genetic Evaluation, Aarhus, Denmark, Denmark
  • Nina Schulmann, MTT Agrifood Research Finland, Jokioinen, Finland, Finland
  • Michel Georges, University of Liège, Liège, Belgium, Belgium
  • Johanna Vilkki, MTT Agrifood Research Finland, Jokioinen, Finland, Finland
  • Mogens Sandø Lund
  • Tom Druet, University of Liège, Liège, Belgium, Belgium
The spectacular increase in productivity of dairy cattle has been accompanied by a decline in fertility. It is assumed that this reduction is due to the negative energy balance of high producing cows. We herein describe the dissection of a fertility QTL in Nordic Red cattle to a 660-Kb deletion on BTa 12. The deletion encompasses four genes and affects fertility by causing death in homozygous embryos. Despite its deleterious effect 32% of the Finnish Ayrshire animals carry the deletion. We show that the deletion has a positive effect on milk yield and that the balancing selection maintains it at a higher frequency. Our study demonstrates the Embryonic lethal mutations are partly responsible for decline in fertility and that associated positive effects on milk yield may partly account for the negative genetic correlation.
Original languageEnglish
Publication year17 Aug 2014
Number of pages3
Publication statusPublished - 17 Aug 2014
Event10th World Congress on Genetics Applied to Livestock Production (WCGALP) - The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4, Vancouver, Canada
Duration: 17 Aug 201422 Aug 2014
Conference number: 10th

Conference

Conference10th World Congress on Genetics Applied to Livestock Production (WCGALP)
Number10th
LocationThe Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4
CountryCanada
CityVancouver
Period17/08/201422/08/2014

    Research areas

  • balancing selection, fertility, embryonic lethals

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