40 years of IGF1: PAPP-A and cancer

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DOI

The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

Original languageEnglish
JournalJournal of Molecular Endocrinology
Volume61
Issue1
Pages (from-to)T1-T10
Number of pages10
ISSN0952-5041
DOIs
Publication statusPublished - 1 Jul 2018

    Research areas

  • Breast cancer, Ewing sarcoma, Insulin-like growth factor, Lung cancer, Melanoma, Mesothelioma, Ovarian cancer, Pregnancy-associated plasma protein-A, Stanniocalcin

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