3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Yingchun Su; Mette Steen Toftdal; Alice Le Friec; MD Dong; Xiaojun Han; Menglin Chen

doi:10.1002/smsc.202100003

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Yingchun Su, Mette Steen Toftdal, Alice Le Friec, MD Dong, Xiaojun Han, Menglin Chen

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

76 Citations (Scopus)

Abstract

Electrospinning is considered the most versatile micro-/nanofiber fabrication technology. The electrospun fibers hold high surface area, desired mechanical properties, controlled topography, as well as the ease of biochemical functionalization. The 3D electrospun fibrous structures closely mimic the hierarchical architecture and fibrous features of the extracellular matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue regeneration are thoroughly discussed. Challenges and future scopes related to each field of tissue regeneration are discussed after each subsection. A few examples of liver, kidney, esophageal tissue engineering are also discussed. Finally, the key challenge in the cost-effective upscale of the electrospinning technique to mature and prevalent industrial applications is outlined. Herein, a systematic, thorough summary of the recent evolutions in electrospinning and its emerging applications for a broad range of tissue regenerations is provided.

Original language	English
Article number	2100003
Journal	Small Science
Volume	1
Issue	7
ISSN	2688-4046
DOIs	https://doi.org/10.1002/smsc.202100003
Publication status	Published - Jul 2021

Keywords

3D electrospun structures
native extracellular matrices
tissue engineering
tissue regeneration

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10.1002/smsc.202100003

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title = "3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration",

abstract = "Electrospinning is considered the most versatile micro-/nanofiber fabrication technology. The electrospun fibers hold high surface area, desired mechanical properties, controlled topography, as well as the ease of biochemical functionalization. The 3D electrospun fibrous structures closely mimic the hierarchical architecture and fibrous features of the extracellular matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue regeneration are thoroughly discussed. Challenges and future scopes related to each field of tissue regeneration are discussed after each subsection. A few examples of liver, kidney, esophageal tissue engineering are also discussed. Finally, the key challenge in the cost-effective upscale of the electrospinning technique to mature and prevalent industrial applications is outlined. Herein, a systematic, thorough summary of the recent evolutions in electrospinning and its emerging applications for a broad range of tissue regenerations is provided.",

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AU - Su, Yingchun

AU - Toftdal, Mette Steen

AU - Friec, Alice Le

AU - Dong, MD

AU - Han, Xiaojun

AU - Chen, Menglin

PY - 2021/7

Y1 - 2021/7

N2 - Electrospinning is considered the most versatile micro-/nanofiber fabrication technology. The electrospun fibers hold high surface area, desired mechanical properties, controlled topography, as well as the ease of biochemical functionalization. The 3D electrospun fibrous structures closely mimic the hierarchical architecture and fibrous features of the extracellular matrices (ECM), which greatly contribute to biomaterials design to stimulate tissue regeneration. Herein, the recent advances in electrospinning technology for 3D production of ECM-mimicking biomaterial scaffolds are systematically summarized and the applications in neural, cardiac, bone, skin, and vascularized tissue regeneration are thoroughly discussed. Challenges and future scopes related to each field of tissue regeneration are discussed after each subsection. A few examples of liver, kidney, esophageal tissue engineering are also discussed. Finally, the key challenge in the cost-effective upscale of the electrospinning technique to mature and prevalent industrial applications is outlined. Herein, a systematic, thorough summary of the recent evolutions in electrospinning and its emerging applications for a broad range of tissue regenerations is provided.

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3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

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Keywords

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