2'-phosphodiesterase and 2',5'-oligoadenylate synthetase activities in the lowest metazoans, sponge [porifera]

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  • Emilie Saby, Denmark
  • Jesper Buchhave Poulsen, Denmark
  • Just Justesen, Denmark
  • Merike Kelve, Denmark
  • Maria Jesus Uriz, Denmark
  • Department of Molecular Biology
Sponges [porifera], the most ancient metazoans, contain modules related to the vertebrate immune system, including the 2′,5′-oligoadenylate synthetase (OAS). The components of the antiviral 2′,5′-oligoadenylate (2–5A) system (OAS, 2′-Phosphodiesterase (2′-PDE) and RNAse L) of vertebrates have not all been identified in sponges. Here, we demonstrate for the first time that in addition to the OAS activity, sponges possess a 2′-PDE activity, which highlights the probable existence of a premature 2–5A system. Indeed, Suberites domuncula and Crella elegans exhibited this 2–5A degrading activity. Upon this finding, two out of three elements forming the 2–5A system have been found in sponges, only a endoribonuclease, RNAse L or similar, has to be found. We suspect the existence of a complex immune system in sponges, besides the self/non-self recognition system and the use of phagocytosis and secondary metabolites against pathogens.

Original languageEnglish
JournalBiochimie
Volume91
Issue11-12
Pages (from-to)1531-1534
Number of pages4
ISSN0300-9084
DOIs
Publication statusPublished - 6 Aug 2009

    Research areas

  • Sponge, Oligoadenylate synthetase, 2′-phosphodiesterase, Activity

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