2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

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  • Fabrizio Albarello, L. Spallanzani IRCCS
  • ,
  • Elisa Pianura, L. Spallanzani IRCCS
  • ,
  • Federica Di Stefano, L. Spallanzani IRCCS
  • ,
  • Massimo Cristofaro, L. Spallanzani IRCCS
  • ,
  • Ada Petrone, L. Spallanzani IRCCS
  • ,
  • Luisa Marchioni, L. Spallanzani IRCCS
  • ,
  • Claudia Palazzolo, L. Spallanzani IRCCS
  • ,
  • Vincenzo Schininà, L. Spallanzani IRCCS
  • ,
  • Emanuele Nicastri, L. Spallanzani IRCCS
  • ,
  • Nicola Petrosillo, L. Spallanzani IRCCS
  • ,
  • Paolo Campioni, L. Spallanzani IRCCS
  • ,
  • Petersen Eskild
  • Alimuddin Zumla, University College London
  • ,
  • Giuseppe Ippolito, L. Spallanzani IRCCS
  • ,
  • COVID 19 INMI Study Group

Introduction: Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar to those seen previously in SARS-CoV and MERS-CoV infected patients. Objective: We present some remarkable imaging findings of the first two patients identified in Italy with COVID-19 infection travelling from Wuhan, China. The follow-up with chest X-Rays and CT scans was also included, showing a progressive adult respiratory distress syndrome (ARDS). Results: Moderate to severe progression of the lung infiltrates, with increasing percentage of high-density infiltrates sustained by a bilateral and multi-segmental extension of lung opacities, were seen. During the follow-up, apart from pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction was seen, mainly found in the dichotomic tracts, where the center of a new insurgent pulmonary lesion was seen. It could be an early alert radiological sign to predict initial lung deterioration. Another uncommon element was the presence of mediastinal lymphadenopathy with short-axis oval nodes. Conclusions: Although only two patients have been studied, these findings are consistent with the radiological pattern described in literature. Finally, the pulmonary vessels enlargement in areas where new lung infiltrates develop in the follow-up CT scan, could describe an early predictor radiological sign of lung impairment.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume93
Pages (from-to)192-197
Number of pages6
ISSN1201-9712
DOIs
Publication statusPublished - Apr 2020

    Research areas

  • COVID-19, Crazy-paving, CT-scan, Enlarged pulmonary vessels, Ground glass opacities, SARS-COV2

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