[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • A. Gerhard, Imperial College London, London, UK., Hammersmith Hospital
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  • R. B. Banati, Imperial College London, London, UK.
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  • G. B. Goerres, Imperial College London, London, UK.
  • ,
  • A. Cagnin, Imperial College London, London, UK.
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  • R. Myers, Imperial College London, London, UK., Hammersmith Hospital
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  • R. N. Gunn, Imperial College London, London, UK., Montreal Neurological Institute
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  • F. Turkheimer, Imperial College London, London, UK., Hammersmith Hospital
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  • C. D. Good, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
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  • C. J. Mathias, Imperial College London, London, UK., Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
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  • N. Quinn, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • J. Schwarz
  • D. J. Brooks

Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.

Original languageEnglish
JournalNeurology
Volume61
Issue5
Pages (from-to)686-689
Number of pages4
ISSN0028-3878
DOIs
Publication statusPublished - 9 Sep 2003

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