1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study

Pamela S Douglas, Bernard De Bruyne, Gianluca Pontone, Manesh R Patel, Bjarne L Norgaard, Robert A Byrne, Nick Curzen, Ian Purcell, Matthias Gutberlet, Gilles Rioufol, Ulrich Hink, Herwig Walter Schuchlenz, Gudrun Feuchtner, Martine Gilard, Daniele Andreini, Jesper Møller Jensen, Martin Hadamitzky, Karen Chiswell, Derek Cyr, Alan WilkFurong Wang, Campbell Rogers, Mark A Hlatky, PLATFORM Investigators

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Background Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFR CT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. Objectives The study sought to determine the 1-year clinical, economic, and quality-of-life (QOL) outcomes of using FFR CT instead of usual care. Methods Consecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFR CT (submitted in 201, analyzed in 177); 581 of 584 (99.5%) completed 1-year follow-up. Endpoints were adjudicated major adverse cardiac events (MACE) (death, myocardial infarction, unplanned revascularization), total medical costs, and QOL. Results Patients averaged 61 years of age with a mean 49% pre-test probability of coronary artery disease. At 1 year, MACE events were infrequent, with 2 in each arm of the planned invasive group and 1 in the planned noninvasive cohort (usual care strategy). In the planned invasive stratum, mean costs were 33% lower with CTA and selective FFR CT ($8,127 vs. $12,145 usual care; p < 0.0001); in the planned noninvasive stratum, mean costs did not differ when using an FFR CT cost weight of zero ($3,049 FFR CT vs. $2,579; p = 0.82), but were higher when using an FFR CT cost weight equal to CTA. QOL scores improved overall at 1 year (p < 0.001), with similar improvements in both groups, apart from the 5-item EuroQOL scale scores in the noninvasive stratum (mean change of 0.12 for FFR CT vs. 0.07 for usual care; p = 0.02). Conclusions In patients with stable chest pain and planned invasive coronary angiography, care guided by CTA and selective FFR CT was associated with equivalent clinical outcomes and QOL, and lower costs, compared with usual care over 1-year follow-up.

Original languageEnglish
JournalJournal of the American College of Cardiology
Pages (from-to)435-445
Number of pages11
Publication statusPublished - 2 Aug 2016


  • Journal Article
  • major adverse cardiac events
  • fractional flow reserve using computed tomography
  • economic outcomes
  • quality of life


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