Abstract
AIM: To observe the distribution of advanced glycation end products (AGEs) and their receptor (RAGE) in the stomach of diabetic rats.
METHODS: Diabetes mellitus (DM) and control (CON) rats were reared for eight weeks. Fasting plasma glucose (FPG), glycated serum protein (GSP) and gastric layer thickness were measured. The expression of AGEs and RAGE was detected by immunohistochemical staining.
RESULTS: The thickness of the mucosa (781.47 µm ± 137.82 µm vs 709.85 µm ± 169.41 µm) and submucosa (233.39 µm ± 134.05 µm vs 109.32 µm ± 44.43 µm) increased significantly in the DM group compared with the CON group (P < 0.05). The expression of AGEs and RAGE in the mucosa (5.66 ± 1.90 vs 2.25 ± 0.52, 2.79 ± 0.54 vs 1.70 ± 0.30) and muscle (37.37 ± 7.38 vs 24.32 ± 4.02, 4.26 ± 0.80 vs 3.59 ± 0.37) layers of the stomach was significantly higher in the DM group than in the CON group (P < 0.05).
CONCLUSION: The expression of AGEs and RAGE is up-regulated in the stomach of diabetic rats. The increased levels of AGE and RAGE in gastric tissue may contribute to diabetic gastrointestinal dysfunction.
© 2015 Baishideng Publishing Group Inc. All rights reserved.
Key Words: Diabetes mellitus; Stomach; Advanced glycation end products; Receptor for advanced glycation end products
| Translated title of the contribution | Distribution of advanced glycation end products and their receptor in the stomach of diabetic rats |
|---|---|
| Original language | Chinese |
| Journal | Shijie Huaren Xiaohua Zazhi |
| Volume | 23 |
| Issue | 17 |
| Pages (from-to) | 2714-2721 |
| Number of pages | 8 |
| ISSN | 1009-3079 |
| Publication status | Published - 18 Jun 2015 |
Keywords
- Diabetes mellitus; Stomach; Advanced glycation end products; Receptor for advanced glycation end products