Study on genetic and epigenetic regulation of host-pathogen interactions in lentiviral infection in sheep

Nowadays, viruses are at the top of the biggest threats to human and animal health and safety. Minimalizing public health threats by eradication risk factors is currently the biggest concern. However, host-pathogen interactions are complex processes, that are mostly understudied. It was discovered that viruses not only integrate with the host’s genome but also can hijack its epigenome to evade antiviral responses. Small ruminant viruses infect animals worldwide causing pain, inevitable death, lower productivity, and consequently significant economic losses. Identification of virus-driven modifications of the host’s epigenetic machinery will contribute to a better understanding of host-pathogen interactions during infection. This information could potentially be used to find better tools and markers to fight viruses in sheep.