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Neonatal hyperbilirubinemia and bilirubin induced neurologic dysfunction (BIND)

Project: Research

  • University of Southern Denmark
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Description

Extreme neonatal hyperbilirubinemia has largely decreased in the last decades, but moderate hyperbilirubinemia, which may cause subtle bilirubin-induced neurological dysfunction (BIND), is much more prevalent and of concern. More evidence is needed to be able to improve prevention. We will use data on clinical measurements of bilirubin in neonates born in two regions in Denmark (1997-2016) and estimate the association between hyperbilirubinemia and BIND outcomes: 1) developmental milestones in early life, 2) neurologic or neuropsychiatric disorders including autism spectrum disorder (ASD), cerebral palsy, attention deficit hyperactivity disorder (ADHD), auditory neuropathic disorder, epilepsy, and mental retardation, and 3) school performance. We will explore potential dose-response effects in these associations. Furthermore, we will apply a regression discontinuity (RD) design, which is a quasi-experimental study design allowing for rigorous causal inference, to estimate the causal treatment effect of phototherapy in preventing BIND in children with hyperbilirubinemia.

Key findings

We have published one paper 'Maimburg RD, Olsen J, Sun Y. Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. Epilepsy research 2016;124:67-72', which showed that phototherapy for hyperbilirubinemia in newborns was associated with an increased risk of epilepsy for males in early childhood.
More findings will be expected in 2021.
Short titleHyperbilirubinemia and BIND
StatusActive
Effective start/end date01/07/201930/06/2023

ID: 202546176