Neonatal hyperbilirubinemia

Project: Research

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Neonatal jaundice is a common condition encountered during the neonatal period, especially in the first week of life . In most neonates, jaundice reflects a normal transitional phenomenon. However, about 4-8% of neonates develop hyperbilirubinemia, excessively high levels of bilirubin, requiring medical attention . Phototherapy is the primary treatment of choice and neonates receive treatment based on whether their level of serum bilirubin is above or below threshold value. Evidence has indicated that levels of bilirubin previously thought to be safe may prove harmful. Thus, the threshold at which bilirubin may be neurotoxic, particularly in subgroups such as premature babies and those with low birth weight, are yet unclear.
Since neonatal bilirubin-induced brain injury is preventable, but extremely difficult to reverse once it occur, it is highly important to gain a better understanding of neonatal hyperbilirubinemia. Such knowledge may permit more target-specific prevention or treatment approaches, which in turn could reduce the risk of neurologic and developmental disorders.
Effective start/end date01/04/2018 → …

ID: 129078937