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Pigs without antibiotics: A pig model of colitis-complex diarrhea with focus on colonic microbial fermentation

Project: Research

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Description

Diarrhea in weaned pigs is one of the major causes of antimicrobial use in pig production. When pigs are 7-12 weeks of age, heavier and therefore takes larger doses of antibiotics to treat than right after weaning, a second phase of diarrhea typically occurs; the colonic colitis-complex diarrhea (CCD). In order to reduce the need for antibiotics, a new and deeper understanding of the colonic microbial fermentation pattern in the pathogenesis of CCD is needed and how this fermentation can be modulated by dietary means to prevent or alleviate CCD.

In this project we will characterize the microbial composition and fermentation pattern in feces from commercial pigs with and without CCD and use this knowledge to establish a new CCD experimental disease model in pigs. Finally, we will test the model and investigate if inclusion of high-amylose maize starch (HAMS) high in resistant starch and butyrylated HAMS can prevent or reduce CCD.

StatusActive
Effective start/end date01/01/202031/12/2022

ID: 175421402