Getting Stuck - How Gram Positive Bacteria Form Biofilm

Project: Research

  • Okshevsky, Mira Ursula, (Participant)
  • Zeng, Guanghong, (Participant)
  • Greve, Matilde (Participant)
  • Meyer, Rikke Louise (Participant)
See relations at Aarhus University

Description

Our perception of microbial life was fundamentally altered when it was discovered that most bacteria live not as free-swimming cells in suspension, but as sessile microbial communities attached to surfaces and encapsulated in a matrix of polymeric substances: a biofilm [1]. Life in a biofilm provides protection from desiccation, predators, biocides, antibiotics, and even the human immune system. Biofilm-forming bacteria are therefore particularly difficult to eradicate. The Holy Grail in biofilm research is to develop new control strategies that target biofilm formation, rather than subsequent removal, by hindering the biological processes responsible for biofilm formation. Development of such strategies requires a detailed and fundamental understanding of the biological mechanisms controlling bacterial attachment.
Biomolecules on the cell surface are central to bacterial attachment as they control the cell-to-surface and cell-to-cell interactions leading to attachment. These interactions include both non-specific physicochemical interactions, and specific adhesin-receptor binding. Although we know some of the biomolecules involved, the exact mechanism behind their function remains elusive for many.
The vision of this Sapere Aude project is to determine how particular biomolecules on the cell surface regulate the cell surface properties and mediate biofilm formation. The objective missions are:
1) To identify biomolecules that control surface properties and attachment of bacterial cells, and
2) To determine the specific mechanisms with which such biomolecules assist biofilm formation.
StatusFinished
Effective start/end date01/11/201231/10/2016

Research outputs

ID: 128992937