About Aarhus University
Genomic Improvement in Fertility Traits in Danish and Brazilian Cattle
Project: Research
- Pedersen, Hanne Skovsgaard (Participant)
- Villemoes, Klaus (Participant)
- Pedersen, Anette Møjbæk (Participant)
- Adamsen, Janne B Funch (Participant)
- Kristensen, Ruth (Participant)
- Callesen, Henrik (Participant)
- Kadarmideen, Haja (Participant)
- Hyttel, Poul (Participant)
- Strøbech, Lotte (Participant)
- Nogueira, Marcelo (Participant)
- KU Health
- Embryo Trans Biotech ApS
- Universidade de Sao Paulo
Description
The GIFT project conducts quantitative genetics and animal breeding research on important attributes or traits related to Ovum Pick-Up (OPU) and in vitro production (IVP) of embryos and contributes to profitability of OPU-IVP operations in the Brazilian and Danish cattle industry. Further, we use Vitrogen company data collected in 5-6 large experimental farms in the state of São Paulo to identify high genetic merit donor cows and recipient heifers with higher pregnancy rates via Genome-Wide Association Studies (GWAS) and Genomic Selection (GS) for OPU-IVP and pregnancy traits in several thousands of Brazilian cattle.
In Denmark, transcriptomics experiments using RNAseq profiles of OPU-IVP recipient cows will be conducted to identify differentially expressed genes and gene regulatory networks in maternal-conceptus tissues in recipient cows that do and do not maintain pregnancy.
Further, we compare conventional in vitro maturation (conIVM) versus Simulated Physiological Oocyte Maturation (SPOM) systems in both Bos taurus and Bos indicus breeds at the level of a) ultra-structural differences in the matured oocyte, b) gene expression in the blastocyst produced in vitro and c) pregnancy rates in recipient cows after transfer of embryos produced in vitro.
Finally, based on the results, we develop and deliver tools for genomic improvement of OPU-IVP and heifer pregnancy traits for practice by Brazilian and Danish companies.
| Acronym | GIFT |
|---|---|
| Status | Finished |
| Effective start/end date | 01/01/2013 → 01/03/2017 |
| Links | http://gift.ku.dk/ |
Links
Project relations
OPU og IVP hos kvæg
Project: Research
Research outputs
In vitro production of bovine embryos - revisiting oocyte development and application of systems biology
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference article › Research › peer-review
Genomic Selection of In vitro Produced and Somatic Cell Nuclear Transfer Embryos for Rapid Genetic Improvement in Cattle Production
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference article › Research › peer-review
In vitro production of bovine embryos: cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Application of integrative genomics and systems biology to conventional and in-vitro reproductive traits in cattle
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Identification of potential biomarkers in donor cows for in vitro embryo production by granulosa cell transcriptomics
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Danmark og Brasilien samarbejder om at forbedre frugtbarheden hos køer
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
Effects of post-mortem storage conditions of bovine epididymides on sperm characteristics: investigating a tool for preservation of sperm from endangered species.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
RNA-Seq transcriptomics analyses to identify biomarkers for in vitro production of embryos in cows
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Basic and practical aspects of pregnancy establishment in cattle
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Prematuration of bovine cumulus-oocyte complexes with cyclic adenosine monophosphate modulators affects both oocyte and blastocyst ultrastructure
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Effect of different reproductive biotechnologies (AI, ET-in vivo and ET-in vitro) on reproductive performance of Holstein females
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review
Systems biology analysis for the identification of biological processes and candidate genes for the prediction of oocyte donor cow quality for IVP
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review
Simulated physiological oocyte maturation has side effects on bovine oocytes and embryos
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Bovine in-vitro produced embryos: development of embryo proper and associated membranes from day 26 to 47 of gestation
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Characterization of the Endometrial Transcriptome in Early Diestrus Influencing Pregnancy Establishment in Dairy Cattle after Transfer of In-Vitro Produced Embryos
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research
Characterization of the endometrial transcriptome in early diestrus influencing pregnancy status in dairy cattle after transfer of in-vitro produced embryos
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
ID: 129000519