Establishment of the chorioallantoic membrane (CAM) model at Aarhus University Hospital

Project: Research

Project Details

Description

During my research year, I established a tissue model derived from fertilized chicken eggs for use across various research fields. Using our unique method, we achieved robust tumor growth and sustained model viability, and analyzed the tumors with both novel and established techniques to expand the applicability of this model in oncological research. The interventions and imaging modalities used include PET, MRI, dual-tracer autoradiography, proton irradiation, and optical coherence tomography (OCT).

To accomplish this, we also refined various anesthesia methods, both gaseous and injectables, and explored alternative administration routes to simplify handling and workflow.

Key findings

Our results are yet to be published. However, they indicate that the CAM model has been underutilized, especially regarding preclinical proton radiation treatment

Layman's description

I have established an alternative model for use in primarily oncological research at Aarhus University Hospital. We have used fertilized chicken eggs instead of mice to grow tumors and with this model we are able to reduce the number of mice in cancer research.
StatusFinished
Effective start/end date01/02/202431/01/2025

Funding

  • Helga og Peter Kornings Fond: DKK10,000.00
  • Helga og Peter Kornings Fond: DKK10,000.00
  • Danish Cancer Society: DKK120,000.00

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