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Zexi Cai

Accuracy of genomic prediction of dry matter intake in Dutch Holsteins using sequence variants from meta-analyses

Research output: Contribution to book/anthology/report/proceedingArticle in proceedingsResearchpeer-review

  • Birgit Gredler-Grandl, Wageningen University & Research
  • ,
  • B. Raymond, Wageningen University & Research
  • ,
  • G.C.B. Schopen, Wageningen University & Research
  • ,
  • P.K. Chitneedi, Institute for Genome Biology
  • ,
  • Zexi Cai
  • Coralia Ines V Manzanilla Pech
  • Terhi Iso-Touru, Luke Natural Resources Institute Finland, Finland
  • Daniel Fischer, Luke Natural Resources Institute Finland
  • ,
  • Sunduimijid Bolormaa, Agriculture Victoria
  • ,
  • Tatiane C.S. Chud, University of Guelph, Fast Genetics, Saskatoon, SK S7K 2K6, Canada
  • ,
  • F S Schenkel, University of Guelph, Canada
  • Yabing Wang, Alberta Agriculture and Rural Development, Lacombe, Canada, University of Alberta
  • ,
  • Changxi Li, University of Alberta, Alberta Agriculture and Rural Development, Lacombe, Canada
  • ,
  • Dagnachew Hailemariam, University of Alberta, Alberta Agriculture and Rural Development, Lacombe, Canada
  • ,
  • B. Villanueva, Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA-CSIC Crta. de la Coruña km 7.5, 28040 Madrid, Spain
  • ,
  • A. Fernandez, Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA-CSIC Crta. de la Coruña km 7.5, 28040 Madrid, Spain
  • ,
  • C Kuehn, Institute for Genome Biology, Denmark
  • Goutam Sahana
  • M Lidauer, Luke Natural Resources Institute Finland, Finland
  • J.E. Pryce, Agriculture Victoria, La Trobe University, Denmark
  • Oscar González-Recio, Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA-CSIC Crta. de la Coruña km 7.5, 28040 Madrid, Spain, Spain
  • Graham Plastow, University of Alberta
  • ,
  • Christine F. Baes, University of Guelph, University of Bern
  • ,
  • Noureddine Charfeddine, Spanish Confereration of Holstein Associations, Spain
  • Y de Haas, Wageningen University & Research, Netherlands
  • Roel Veerkamp, Wageningen University & Research, Netherlands
  • Aniek C Bouwman, Wageningen University & Research, Unknown
We evaluated the accuracy of biology informed genomic prediction for dry matter intake in 2,162 Dutch Holstein cows. Sequence variants were selected from meta-analyses including GWAS summary statistics for QTL and metabolomic QTL in several dairy and crossbred beef populations. Selected variants were prioritized in GBLUP models in a five-fold crossvalidation. The accuracies were compared to genomic prediction based on routine 50k genotype data. The average accuracy for the 50k scenario was 0.683. Adding selected sequence variants in the GBLUP model did not improve the accuracies for dry matter intake. Next steps will
include testing Bayesian variable selection methods to prioritize variants in genomic prediction for dry matter intake.
Original languageEnglish
Title of host publicationWCGALP 2022 Programme book
Number of pages4
PublisherWageningen Academic Publishers
Publication yearJul 2022
Publication statusPublished - Jul 2022
EventWorld Congress on Genetics Applied to Livestock Production - Rotterdam, Netherlands
Duration: 3 Jul 20228 Jul 2022
Conference number: 12
https://wcgalp.com/

Conference

ConferenceWorld Congress on Genetics Applied to Livestock Production
Nummer12
LandNetherlands
ByRotterdam
Periode03/07/202208/07/2022
Internetadresse

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