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Yuya Hayashi

Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen

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Standard

Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen. / Hayashi, Yuya; Heckmann, Lars-Henrik; Callaghan, Amanda; Sibly, Richard.

In: Ecotoxicology, Vol. 17, No. 4, 2008, p. 246-51.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hayashi, Y, Heckmann, L-H, Callaghan, A & Sibly, R 2008, 'Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen', Ecotoxicology, vol. 17, no. 4, pp. 246-51.

APA

Hayashi, Y., Heckmann, L-H., Callaghan, A., & Sibly, R. (2008). Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen. Ecotoxicology, 17(4), 246-51.

CBE

Hayashi Y, Heckmann L-H, Callaghan A, Sibly R. 2008. Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen. Ecotoxicology. 17(4):246-51.

MLA

Vancouver

Hayashi Y, Heckmann L-H, Callaghan A, Sibly R. Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen. Ecotoxicology. 2008;17(4):246-51.

Author

Hayashi, Yuya ; Heckmann, Lars-Henrik ; Callaghan, Amanda ; Sibly, Richard. / Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen. In: Ecotoxicology. 2008 ; Vol. 17, No. 4. pp. 246-51.

Bibtex

@article{235204604d3411df9806000ea68e967b,
title = "Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen",
abstract = "In mammals, the pharmaceutical ibuprofen (IB), a non-steroidal anti-inflammatory drug, primarily functions by reversibly inhibiting the cyclooxygenase (COX) pathway in the synthesis of eicosanoids (e.g. prostaglandins). Previous studies suggest that IB may act in a similar manner to interrupt production of eicosanoids reducing reproduction in the model crustacean Daphnia magna. On this basis withdrawal of IB should lead to the recovery of D. magna reproduction. Here we test whether the effect of IB is reversible in D. magna, as it is in mammals, by observing reproduction recovery following chronic exposure. D. magna (5-days old) were exposed to a range of IB concentrations (0, 20, 40 and 80 mg L-1) for 10 days followed by a 10 day recovery period in uncontaminated water. During the exposure period, individuals exposed to higher concentrations produced significantly fewer offspring. Thereafter, IB-stressed individuals produced offspring faster during recovery, having similar average population growth rates (PGR) (1.15-1.28) to controls by the end of the test. It appears that maternal daphnids are susceptible to IB during egg maturation. This is the first recorded recovery of reproduction in aquatic invertebrates that suffered reproductive inhibition during chronic exposure to a chemical stressor. Our results suggest a possible theory behind the compensatory fecundity that we referred to as 'catch-up reproduction'.",
author = "Yuya Hayashi and Lars-Henrik Heckmann and Amanda Callaghan and Richard Sibly",
year = "2008",
language = "English",
volume = "17",
pages = "246--51",
journal = "Ecotoxicology",
issn = "0963-9292",
publisher = "Springer New York LLC",
number = "4",

}

RIS

TY - JOUR

T1 - Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen

AU - Hayashi, Yuya

AU - Heckmann, Lars-Henrik

AU - Callaghan, Amanda

AU - Sibly, Richard

PY - 2008

Y1 - 2008

N2 - In mammals, the pharmaceutical ibuprofen (IB), a non-steroidal anti-inflammatory drug, primarily functions by reversibly inhibiting the cyclooxygenase (COX) pathway in the synthesis of eicosanoids (e.g. prostaglandins). Previous studies suggest that IB may act in a similar manner to interrupt production of eicosanoids reducing reproduction in the model crustacean Daphnia magna. On this basis withdrawal of IB should lead to the recovery of D. magna reproduction. Here we test whether the effect of IB is reversible in D. magna, as it is in mammals, by observing reproduction recovery following chronic exposure. D. magna (5-days old) were exposed to a range of IB concentrations (0, 20, 40 and 80 mg L-1) for 10 days followed by a 10 day recovery period in uncontaminated water. During the exposure period, individuals exposed to higher concentrations produced significantly fewer offspring. Thereafter, IB-stressed individuals produced offspring faster during recovery, having similar average population growth rates (PGR) (1.15-1.28) to controls by the end of the test. It appears that maternal daphnids are susceptible to IB during egg maturation. This is the first recorded recovery of reproduction in aquatic invertebrates that suffered reproductive inhibition during chronic exposure to a chemical stressor. Our results suggest a possible theory behind the compensatory fecundity that we referred to as 'catch-up reproduction'.

AB - In mammals, the pharmaceutical ibuprofen (IB), a non-steroidal anti-inflammatory drug, primarily functions by reversibly inhibiting the cyclooxygenase (COX) pathway in the synthesis of eicosanoids (e.g. prostaglandins). Previous studies suggest that IB may act in a similar manner to interrupt production of eicosanoids reducing reproduction in the model crustacean Daphnia magna. On this basis withdrawal of IB should lead to the recovery of D. magna reproduction. Here we test whether the effect of IB is reversible in D. magna, as it is in mammals, by observing reproduction recovery following chronic exposure. D. magna (5-days old) were exposed to a range of IB concentrations (0, 20, 40 and 80 mg L-1) for 10 days followed by a 10 day recovery period in uncontaminated water. During the exposure period, individuals exposed to higher concentrations produced significantly fewer offspring. Thereafter, IB-stressed individuals produced offspring faster during recovery, having similar average population growth rates (PGR) (1.15-1.28) to controls by the end of the test. It appears that maternal daphnids are susceptible to IB during egg maturation. This is the first recorded recovery of reproduction in aquatic invertebrates that suffered reproductive inhibition during chronic exposure to a chemical stressor. Our results suggest a possible theory behind the compensatory fecundity that we referred to as 'catch-up reproduction'.

M3 - Journal article

VL - 17

SP - 246

EP - 251

JO - Ecotoxicology

JF - Ecotoxicology

SN - 0963-9292

IS - 4

ER -