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Department of Biomedicine

Yonglun Luo

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2023
Published
Comparison of In-Frame Deletion, Homology-Directed Repair, and Prime Editing-Based Correction of Duchenne Muscular Dystrophy Mutations. / Zhao, Xiaoying; Qu, Kunli; Curci, Benedetta et al.
In: Biomolecules, Vol. 13, No. 5, 22.05.2023.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Cationic amphiphilic antihistamines inhibit STAT3 via Ca²⁺-dependent lysosomal H⁺ efflux. / Liu, Bin; Chen, Ran; Zhang, Yidan et al.
In: Cell Reports, Vol. 42, No. 2, 112137, 02.2023.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Integrative genetic and single cell RNA sequencing analysis provides new clues to the amyotrophic lateral sclerosis neurodegeneration. / Liu, Hankui; Guan, Liping; Deng, Min et al.
In: Frontiers in Neuroscience, Vol. 17, 1116087, 02.2023.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization. / Song, Qiaoling; Datta, Shyamasree; Liang, Xue et al.
In: Cellular & molecular immunology, Vol. 20, No. 2, 02.2023, p. 143-157.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
E-pub ahead of print
GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation. / Rizza, Salvatore; Di Leo, Luca; Pecorari, Chiara et al.
In: Cell Reports, Vol. 42, No. 1, 18.01.2023, p. 111997.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Single cell and immunity: Better understanding immune cell heterogeneities with single cell sequencing. / Chen, Dongsheng; Luo, Yonglun; Cheng, Genhong.
In: Clinical and Translational Medicine, Vol. 13, No. 1, 01.2023, p. e1159.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research
2022
Published
Author Correction: Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level (Nature Communications, (2022), 13, 1, (3620), 10.1038/s41467-022-31388-z). / Wang, Fei; Ding, Peiwen; Liang, Xue et al.
In: Nature Communications, Vol. 13, No. 1, 6748, 12.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review
Published
HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes. / Brandt, Camilla B.; Fonager, Sofie V.; Haskó, János et al.
In: Biomolecules, Vol. 13, No. 1, 23, 12.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Massively targeted evaluation of therapeutic CRISPR off-targets in cells. / Pan, Xiaoguang; Qu, Kunli; Yuan, Hao et al.
In: Nature Communications, Vol. 13, No. 1, 4049, 12.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Vasculogenesis in kidney organoids upon transplantation. / Koning, Marije; Dumas, Sébastien J.; Avramut, M. Cristina et al.
In: npj Regenerative Medicine, Vol. 7, No. 1, 40, 12.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
The single-cell expression profile of transposable elements and transcription factors in human early biparental and uniparental embryonic development. / Li, Conghui; Zhang, Yue; Leng, Lizhi et al.
In: Frontiers in Cell and Developmental Biology, Vol. 10, 1020490, 11.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency. / Andersen, Olav M ; Bøgh, Nikolaj ; Landau, Anne M et al.
In: Cell Reports Medicine, Vol. 3, No. 9, 100740, 09.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast. / Geldhof, Vincent; de Rooij, Laura P.M.H.; Sokol, Liliana et al.
In: Nature Communications, Vol. 13, 5511, 09.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Extrachromosomal circular DNA in cancer: history, current knowledge, and methods. / Noer, Julie B.; Hørsdal, Oskar K.; Xiang, Xi et al.
In: Trends in Genetics, Vol. 38, No. 7, 07.2022, p. 766-781.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
A Brief Overview of Global Trends in MSC-Based Cell Therapy. / Jovic, Dragomirka; Yu, Yingjia; Wang, Dan et al.
In: Stem Cell Reviews and Reports, Vol. 18, No. 5, 06.2022, p. 1525-1545.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level. / Wang, Fei; Ding, Peiwen; Liang, Xue et al.
In: Nature Communications, Vol. 13, 3620, 06.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context. / Corsi, Giulia I; Qu, Kunli; Alkan, Ferhat et al.
In: Nature Communications, Vol. 13, No. 1, 3006, 05.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Circle-Seq reveals genomic and disease-specific hallmarks in urinary cell-free extrachromosomal circular DNAs. / Lv, Wei; Pan, Xiaoguang; Han, Peng et al.
In: Clinical and Translational Medicine, Vol. 12, No. 4, e817, 04.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Single-cell RNA sequencing technologies and applications: A brief overview. / Jovic, Dragomirka; Liang, Xue; Zeng, Hua et al.
In: Clinical and Translational Medicine, Vol. 12, No. 3, e694, 03.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
Genome-wide annotation of protein-coding genes in pig. / Karlsson, Max; Sjöstedt, Evelina; Oksvold, Per et al.
In: BMC Biology, Vol. 20, 25, 01.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single-cell sequencing. / Li, Zhibin; Sun, Chengcheng; Wang, Fei et al.
In: Clinical and Translational Medicine, Vol. 12, No. 1, e689, 01.2022.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Toward the massive genome of Proteus anguinus-illuminating longevity, regeneration, convergent evolution, and metabolic disorders. / Kostanjšek, Rok; Diderichsen, Børge; Recknagel, Hans et al.
In: Annals of the New York Academy of Sciences, Vol. 1507, No. 1, 01.2022, p. 5-11.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2021
Published
Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia. / Arslanova, Alia; Shafaattalab, Sanam; Ye, Kevin et al.
In: Current Protocols, Vol. 1, No. 12, e320, 12.2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
The Dynamic Changes of Transcription Factors During the Development Processes of Human Biparental and Uniparental Embryos. / Zhang, Chenxi; Li, Conghui; Yang, Ling et al.
In: Frontiers in Cell and Developmental Biology, Vol. 9, 709498, 09.2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer´s Disease. / Andersen, Olav Michael ; Bøgh, Nikolaj ; Landau, Anne et al.
2021.
Research output: Working paper/Preprint › Preprint
Published
A single-cell type transcriptomics map of human tissues. / Karlsson, Max; Zhang, Cheng; Méar, Loren et al.
In: Science Advances, Vol. 7, No. 31, 07.2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer. / Banerjee, Santasree; Zhang, Xianxiang; Kuang, Shan et al.
In: iScience, Vol. 24, No. 7, 102718, 07.2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Phenotypic diversity and metabolic specialization of renal endothelial cells. / Dumas, Sébastien J; Meta, Elda; Borri, Mila et al.
In: Nature Reviews. Nephrology, Vol. 17, No. 7, 07.2021, p. 441-464.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
A porcine brain-wide RNA editing landscape. / Huang, Jinrong; Lin, Lin; Dong, Zhanying et al.
In: Communications Biology, Vol. 4, 06.2021, p. 717.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Efficient correction of Duchenne muscular dystrophy mutations by SpCas9 and dual gRNAs. / Xiang, Xi; Zhao, Xiaoying; Pan, Xiaoguang et al.
In: Molecular Therapy - Nucleic Acids, Vol. 24, 06.2021, p. 403-415.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues. / Berthelsen, Martin Fogtmann; Riedel, Maria; Cai, Huiqiang et al.
In: Cancers, Vol. 13, No. 12, 3024, 06.2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Tumor vessel co-option probed by single-cell analysis. / Teuwen, Laure Anne; De Rooij, Laura P.M.H.; Cuypers, Anne et al.
In: Cell Reports, Vol. 35, No. 11, 109253, 06.2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
A single-cell approach to engineer CD8+ T cells targeting cytomegalovirus. / Wang, Fei; Xu, Qumiao; Zhuang, Zhenkun et al.
In: Cellular & molecular immunology, Vol. 18, 05.2021, p. 1326-1328.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review
Published
Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning. / Xiang, Xi; Corsi, Giulia I; Anthon, Christian et al.
In: Nature Communications, Vol. 12, 3238, 05.2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
A network-based algorithm for the identification of moonlighting noncoding RNAs and its application in sepsis. / Liu, Xueyan; Xu, Yong; Wang, Ran et al.
In: Briefings in bioinformatics, Vol. 22, No. 1, 01.2021, p. 581-588.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes. / Zheng, Tianyu; Huang, Jinrong; Xiang, Xi et al.
In: Cancer Cell International, Vol. 21, No. 1, 530, 2021.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2020
Published
Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs. / Feng, Lizhao; Chao, Jianfei; Tian, E et al.
In: Advanced Science, Vol. 7, No. 23, 2002155, 12.2020.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
GNL-Scorer: A generalized model for predicting CRISPR on-target activity by machine learning and featurization. / Wang, Jun; Xiang, Xi; Bolund, Lars et al.
In: Molecular and Cellular Biology, Vol. 12, No. 11, 11.2020, p. 909-911.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David ; Farahani, Ensieh ; Thyrsted, Jacob et al.
In: Nature Communications, Vol. 11, No. 1, 5419, 21.10.2020.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate/letter to the editor › Research › peer-review
Published
Feeder-free generation and transcriptome characterization of functional mesenchymal stromal cells from human pluripotent stem cells. / Luo, Lidan; Zhou, Yan; Zhang, Chenxi et al.
In: Stem Cell Research, Vol. 48, 101990, 10.2020.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David ; Farahani, Ensieh ; Thyrsted, Jacob et al.
In: Nature Communications, Vol. 11, No. 1, 4938, 10.2020.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
FcRn overexpression in human cancer drives albumin recycling and cell growth: a mechanistic basis for exploitation in targeted albumin-drug designs. / Larsen, Maja Thim; Mandrup, Ole A; Schelde, Karen Kræmmer et al.
In: Journal of Controlled Release, Vol. 322, 06.2020, p. 53-63.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis. / Rohlenova, Katerina; Goveia, Jermaine; García-Caballero, Melissa et al.
In: Cell Metabolism, Vol. 31, No. 4, 04.2020, p. 862-877.e14.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates (vol 37, pg 21.e1, 2020). / Goveia, Jermaine; Rohlenova, Katerina; Taverna, Federico et al.
In: Cancer Cell, Vol. 37, No. 3, 16.03.2020, p. 421-421.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Single-Cell Transcriptome Atlas of Murine Endothelial Cells. / Kalucka, Joanna; de Rooij, Laura P M H; Goveia, Jermaine et al.
In: Cell, Vol. 180, No. 4, 02.2020, p. 764-779.e20.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
An overview and metanalysis of Machine and Deep Learning-Based CRISPR gRNA Design Tools. / Wang, Jun; Zhang, Xiuqing; Cheng, Lixin et al.
In: RNA Biology, Vol. 17, No. 1, 01.2020, p. 13-22.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
Identification and functional characterization of mutations in LPL gene causing severe hypertriglyceridaemia and acute pancreatitis. / Han, Peng; Wei, Guohong; Cai, Ke et al.
In: Journal of Cellular and Molecular Medicine (Online), Vol. 24, No. 2, 01.2020, p. 1286-1299.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation. / Dumas, Sébastien J; Meta, Elda; Borri, Mila et al.
In: Journal of the American Society of Nephrology : JASN, Vol. 31, No. 1, 01.2020, p. 118-138.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. / Goveia, Jermaine; Rohlenova, Katerina; Taverna, Federico et al.
In: Cancer Cell, Vol. 37, No. 1, 2020, p. 21-36.e13.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
An atlas of the protein-coding genes in the human, pig, and mouse brain. / Sjöstedt, Evelina; Zhong, Wen; Fagerberg, Linn et al.
In: Science, Vol. 367, No. 6482, 5947, 2020.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing. / Yu, Jiaying; Xiang, Xi; Huang, Jinrong et al.
In: Nucleic Acids Research, Vol. 48, No. 5, e25, 2020.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution. / Björkman, Andrea; Johansen, Søren L; Lin, Lin et al.
In: Genes & Development, Vol. 34, No. 15-16, 2020, p. 1065-1074.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma. / Thomsen, Emil Aagaard ; Rovsing, Anne Bruun; Anderson, Mads Valdemar et al.
In: Molecular Oncology, Vol. 14, No. 9, 2020, p. 1978-1997.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development. / Nelson, Shannon R; Zhang, Chenxi; Roche, Sandra et al.
In: Scientific Reports, Vol. 10, No. 1, 2778, 2020.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2019
Published
Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing. / Mikkelsen, Rasmus Bjerregaard; Frederiksen, Henriette Reventlow S; Gjerris, Mickey et al.
In: The CRISPR Journal, Vol. 2, No. 6, 12.2019, p. 362-369.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
Published
Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development. / Leng, Lizhi; Sun, Jiya; Huang, Jinrong et al.
In: Cell Stem Cell, Vol. 25, No. 5, 07.11.2019, p. 697-712.e6.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
The metabolic engine of endothelial cells. / Falkenberg, Kim D. ; Rohlenova, Katerina ; Luo, Yonglun et al.
In: Nature Metabolism, Vol. 1, No. 10, 10.2019, p. 937-946.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair. / Korsholm, Lea M; Gál, Zita; Lin, Lin et al.
In: Nucleic Acids Research, Vol. 47, No. 15, 05.09.2019, p. 8019-8035.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Refining CRISPR-based genome and epigenome editing off-targets. / Luo, Yonglun.
In: Cell Biology and Toxicology, Vol. 35, No. 4, 08.2019, p. 281-283.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial
Published
LION: a simple and rapid method to achieve CRISPR gene editing. / Xiang, Xi; Luo, Lidan; Nodzyński, Michał et al.
In: Cellular and Molecular Life Sciences, Vol. 76, No. 13, 07.2019, p. 2633-2645.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
CRISPR/Cas9-Mediated Gene Tagging: A Step-by-Step Protocol. / Xiang, Xi; Li, Conghui; Chen, Xi et al.
CRISPR gene editing. ed. / Younglun Luo. New York: Humana Press, 2019. p. 255-269 (Methods in Molecular Biology, Vol. 1961).
Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
Published
Functional Evaluation of CRISPR Activity by the Dual-Fluorescent Surrogate System: C-Check. / Lin, Lin ; Luo, Yonglun.
CRISPR Gene Editing: Methods and Protocols. ed. / Yonglun Luo. Springer Science+Business Media, 2019. p. 67-77 (Methods in Molecular Biology, Vol. 1961).
Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
Published
Population Genomics of an Obligately Halophilic Basidiomycete Wallemia ichthyophaga. / Gostinčar, Cene; Sun, Xiaohuan ; Zajc, Janja et al.
In: Frontiers in Microbiology, Vol. 10, 2019.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Rapid and Efficient Gene Deletion by CRISPR/Cas9. / Neldeborg, Signe ; Lin, Lin ; Stougaard, Magnus et al.
CRISPR Gene Editing: Methods and Protocols. Humana Press, 2019. p. 233-247 (Methods in Molecular Biology, Vol. 1961).
Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
Published
Tracking CRISPR's Footprints. / Lin, Lin ; Luo, Yonglun.
CRISPR Gene Editing: Methods and Protocols. ed. / Yonglun Luo. Springer Science+Business Media, 2019. p. 13-28 (Methods in Molecular Biology, Vol. 1961).
Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
2018
Published
CRISPR-C: circularization of genes and chromosome by CRISPR in human cells. / Møller, Henrik Devitt; Lin, Lin; Xiang, Xi et al.
In: Nucleic Acids Research, Vol. 46, No. 22, 14.12.2018, p. e131.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH. / Liu, Bin; Palmfeldt, Johan ; Lin, Lin et al.
In: Cell Research, Vol. 28, No. 10, 10.2018, p. 996–1012.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. / Olagnier, David ; Brandtoft, Aske M; Gunderstofte, Camilla et al.
In: Nature Communications, Vol. 9, No. 1, 3506, 29.08.2018.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Simple method for assembly of CRISPR synergistic activation mediator gRNA expression array. / Vad-Nielsen, Johan ; Nielsen, Anders Lade ; Luo, Yonglun.
In: Journal of Biotechnology, Vol. 274, 20.05.2018, p. 54-57.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases. / Lin, Lin; Liu, Yong; Xu, Fengping et al.
In: GigaScience, Vol. 7, No. 3, 01.03.2018, p. 1-19.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Central and peripheral nervous system progenitors derived from human pluripotent stem cells reveal a unique temporal and cell-type specific expression of PMCAs. / Chen, Muwan; Laursen, Sofie H.; Habekost, Mette et al.
In: Frontiers in Cell and Developmental Biology, Vol. 6, 5, 06.02.2018.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Genetically Engineered Pig Models for Human Diseases using ZFNs, TALENs and CRISPR/Cas9. / Berthelsen, Martin F.; Thomsen, Martin K.; Luo, Yonglun.
Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery. Cambridge University Press, 2018. p. 110-131.
Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
2017
Published
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. / Niu, Dong; Wei, Hong-Jiang; Lin, Lin et al.
In: Science, Vol. 357, No. 6357, 22.09.2017, p. 1303-1307.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Chromatin accessibility and guide sequence secondary structure affect CRISPR-Cas9 gene editing efficiency. / Jensen, Kristopher Torp; Fløe, Lasse; Petersen, Trine Skov et al.
In: FEBS Letters, Vol. 591, No. 13, 05.06.2017, p. 1892-1901.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts. / Xiong, Kai; Zhou, Yan; Blichfeld, Kristian Aabo et al.
In: Cellular reprogramming, Vol. 19, No. 3, 06.2017, p. 189-198.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells. / Hussmann, Dianna; Madsen, Anne Tranberg; Jakobsen, Kristine Raaby et al.
In: OncoTarget, Vol. 8, 18.03.2017.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene. / Toustrup, Lise Bols ; Zhou, Yan; Kvistgaard, Helene et al.
In: Stem Cell Research, Vol. 19, 03.2017, p. 37-42.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Mitochondrial Spare Respiratory Capacity Is Negatively Correlated With Nuclear Reprogramming Efficiency. / Zhou, Yan; Al-Saaidi, Rasha Abdelkadhem; Guerra, Paula Fernandez et al.
In: Stem Cells and Development, Vol. 26, No. 3, 02.2017, p. 166-176.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Evaluation of porcine stem cells competence for somatic cell nuclear transfer and production of cloned animals. / Secher, Jan; Liu, Ying; Petkov, Stoyan et al.
In: Animal Reproduction Science, Vol. 178, 2017, p. 40-49.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells. / Lin, Lin ; Petersen, Trine Skov; Jensen, Kristopher Torp et al.
In: Journal of Biotechnology, Vol. 247, 2017, p. 42-29.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. / Zhang, Yu; Schmid, Benjamin; Nikolaisen, Nanett Kvist et al.
In: Stem Cell Reports, Vol. 8, No. 3, 2017.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells. / Secher, Jan O; Ceylan, Ahmet; Mazzoni, Gianluca et al.
In: Molecular Reproduction and Development, Vol. 84, No. 3, 2017, p. 229-245.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
The Effects of Voluntary Physical Exercise-Activated Neurotrophic Signaling in Rat Hippocampus on mRNA Levels of Downstream Signaling Molecules. / Sølvsten, Christina; Daugaard, Tina Fuglsang ; Luo, Yonglun et al.
In: Journal of Molecular Neuroscience, Vol. 62, No. 2, 2017, p. 142-153.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2016
Published
A Golden Gate-based Protocol for Assembly of Multiplexed gRNA Expression Arrays for CRISPR/Cas9. / Vad-Nielsen, Johan ; Lin, Lin; Jensen, Kristopher Torp et al.
In: Bio-protocol, Vol. 6, No. 23, e2059, 05.12.2016.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM). / Xiong, Kai; Zhou, Yan ; Hyttel, Poul et al.
In: Stem Cell Research, Vol. 17, No. 3, 17.11.2016, p. 665-669.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
CRISPR-mediated multiplexed genetic manipulation. / Lin, Lin ; Vad-Nielsen, Johan ; Luo, Yonglun.
In: OncoTargets and Therapy, 15.11.2016.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
The CRISPR-Cas9 Minipig. / Berthelsen, Martin Fogtmann; Møller, Simone; Callesen, Henrik et al.
2016.
Research output: Contribution to conference › Conference abstract for conference › Research
Published
Golden Gate Assembly of CRISPR gRNA expression array for simultaneously targeting multiple genes. / Vad-Nielsen, Johan ; Lin, Lin ; Bolund, Lars et al.
In: Cellular and Molecular Life Sciences, Vol. 73, No. 22, 13.05.2016, p. 4315–4325.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Pig model for diabetes. / Luo, Yonglun (Inventor); Bolund, Lars (Inventor).
Mar 03, 2016.
Research output: Patent
Published
Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system. / Zhou, Yan; Liu, Yong; Hussmann, Dianna et al.
In: Cellular and Molecular Life Sciences, Vol. 73, No. 13, 11.01.2016, p. 2543-63.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Genetically modified pig models for neurodegenerative disorders. / Holm, Ida E; Alstrup, Aage Kristian Olsen ; Luo, Yonglun.
In: Journal of Pathology, Vol. 238, No. 2, 01.2016, p. 267-87.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review
Published
Precision Epigenome Editing – Promise and Challenge. / Fløe, Lasse; Luo, Yonglun.
In: Biozoom, No. 4, 2016.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Communication
Published
Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors. / Cai, Yujia; Laustsen, Anders ; Zhou, Yan et al.
In: eLife, Vol. 5, 2016.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
2015
Published
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. / Luo, Yonglun ; Blechingberg, Jenny; Fernandes, Ana Miguel et al.
In: BMC Genomics, Vol. 16, No. 1, 929, 14.11.2015.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. / Luo, Yonglun ; Friis, Jenny Blechingberg; Fernandes, Ana Miguel et al.
In: BMC Genomics, Vol. 16, 11.2015.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
The Epigenetic Reprogramming Roadmap in Generation of iPSCs from Somatic Cells. / Brix, Jacob; Zhou, Yan ; Luo, Yonglun.
In: Journal of Genetics and Genomics, 10.2015.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Towards personalized regenerative cell therapy: Mesenchymal stem cells derived from human induced pluripotent stem cells. / Lin, Lin ; Bolund, Lars ; Luo, Yonglun.
In: Current Stem Cell Research & Therapy, 23.07.2015.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity. / Kang, Ran; Zhou, Yan; Tan, Shuang et al.
In: Stem Cell Research & Therapy, Vol. 6, No. 1, 2015, p. 144.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Published
Targeted Porcine Genome Engineering with TALENs. / Luo, Yonglun ; Lin, Lin; Golas, Mariola Monika et al.
Somatic Genome Manipulation : Advances, Methods and Applications. Springer New York, 2015. p. 17-33.
Research output: Contribution to book/anthology/report/proceeding › Book chapter › Research › peer-review
2014
Published
Clock-controlled StAR's expression and corticosterone production contribute to the endotoxemia immune response. / Wang, Jiesi; Luo, Yonglun; Wang, KangLi et al.
In: Chronobiology International, 25.11.2014, p. 1-10.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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