Won Yong Kim

ST peak during primary percutaneous coronary intervention predicts final infarct size, left ventricular function, and clinical outcome

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Jacob Thomsen Lønborg, Kliniske Institutter, Denmark
  • Henning Skov Kelbæk, Kliniske Institutter, Denmark
  • Lene Holmvang, SUND ph.d. skole, Denmark
  • Niels Grove Vejlstrup, SUND ph.d. skole, Denmark
  • Erik Jørgensen, Kliniske Institutter, Denmark
  • Steffen Helqvist, Kliniske Institutter, Denmark
  • Kari Saunamäki
  • ,
  • Nadia P Dridi
  • ,
  • Kiril Aleksov Ahtarovski
  • ,
  • Christian Juhl Terkelsen
  • Hans Erik Bøtker
  • Won Yong Kim
  • Marek Treiman, Afd. for Hjerte- og Kredsløbsforskning, Denmark
  • Peter Clemmensen, Kliniske Institutter, Denmark
  • Thomas Engstrøm, SUND ph.d. skole, Denmark
BACKGROUND AND PURPOSE: One third of patients treated with primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction develop a secondary increase in electrocardiographic ST segment (ST peak) during reperfusion. The purpose was to determine the clinical importance of ST peak during primary PCI. METHODS: A total of 363 patients with ST-elevation myocardial infarction were stratified to no ST peak or ST peak. Final infarct size and ejection fraction (EF) were assessed by cardiovascular magnetic resonance. RESULTS: Patients with ST peak had a larger infarct size (14% vs 10%; P = .003) and lower EF (53% vs 57%; P = .022). Rates of cardiac mortality (8% vs 3%; P = .047) and cardiac events (cardiac mortality and admission for heart failure; 19% vs 10%; P = .018) were higher among patients with ST peak, but not all-cause mortality (8% vs 5%; P = .46). In a multivariable Cox regression analysis, ST peak remained significantly associated with cardiac events (adjusted hazard ratio, 2.03 [1.08-3.82]). CONCLUSION: ST peak during primary PCI is related to larger final infarct size, a reduced EF, and adverse cardiac clinical outcome.
Original languageEnglish
JournalJournal of Electrocardiology
Volume45
Issue6
Pages (from-to)708-716
Number of pages9
ISSN0022-0736
DOIs
Publication statusPublished - Nov 2012

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